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Titolo:
The cytoskeleton of digestive epithelia in health and disease
Autore:
Ku, NO; Zhou, XJ; Toivola, DM; Omary, MB;
Indirizzi:
Vet Affairs Palo Alto Hlth Care Syst, Dept Med, Palo Alto, CA 94304 USA Vet Affairs Palo Alto Hlth Care Syst Palo Alto CA USA 94304 CA 94304 USA Stanford Univ, Sch Med, Ctr Digest Dis, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 tr Digest Dis, Stanford, CA 94305 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
fascicolo: 6, volume: 277, anno: 1999,
pagine: G1108 - G1137
SICI:
0193-1857(199912)277:6<G1108:TCODEI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYPEPTIDE-SPECIFIC-ANTIGEN; KERATIN INTERMEDIATE FILAMENTS; MICROTUBULE-ASSOCIATED PROTEIN; HEPATOCYTE PLASMA-MEMBRANE; MULTIPLE-DRUG RESISTANCE; PANCREATIC ACINAR-CELLS; ACTIN-BINDING PROTEINS; MALLORY BODY FORMATION; CHRONIC LIVER-DISEASE; BREAST-CANCER CELLS;
Keywords:
microfilaments; microtubules; intermediate filaments; keratins; actin; tubulin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
277
Recensione:
Indirizzi per estratti:
Indirizzo: Omary, MB Palo Alto VA Med Ctr, 3801 Miranda Ave,154-J, Palo Alto, CA 94304 USA Palo Alto VA Med Ctr 3801 Miranda Ave,154-J Palo Alto CA USA 94304
Citazione:
N.O. Ku et al., "The cytoskeleton of digestive epithelia in health and disease", AM J P-GAST, 277(6), 1999, pp. G1108-G1137

Abstract

The mammalian cell cytoskeleton consists of a diverse group of fibrillar elements that play a pivotal role in mediating a number of digestive and nondigestive cell functions, including secretion, absorption, motility, mechanical integrity, and mitosis. The cytoskeleton of higher-eukaryotic cells consists of three highly abundant major protein families: microfilaments (MF), microtubules (MT), and intermediate filaments (IF), as well as a growing number of associated proteins. Within digestive epithelia, the prototype members of these three protein families are actins, tubulins, and keratins, respectively. This review highlights the important structural, regulatory, functional, and unique features of the three major cytoskeletal protein groups in digestive epithelia. The emerging exciting biological aspects of these protein groups are their involvement in cell signaling via direct or indirect interaction with a growing list of associated proteins (MF, MT, IF), the identification of several disease-causing mutations (IF, MF), the functional role that they play in protection from environmental stresses (IF), and their functional integration via several linker proteins that bridge two or potentially ail three of these groups together. The use of agents that target specific cytoskeletal elements as therapeutic modalities for digestive diseases offers potential unique areas of intervention that remain to be fully explored.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 22:29:35