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Titolo:
Pancreatic innervation is not essential for exercise-induced changes in glucagon and insulin or glucose kinetics
Autore:
Coker, RH; Koyama, Y; Lacy, DB; Williams, PE; Rheaume, N; Wasserman, DH;
Indirizzi:
Vanderbilt Univ, Sch Med, Ctr Diabet Res & Training, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Training, Nashville, TN 37232 USA Vanderbilt Univ, Sch Med, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 & Biophys, Nashville, TN 37232 USA Vanderbilt Univ, Sch Med, Dept Surg, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Dept Surg, Nashville, TN 37232 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
fascicolo: 6, volume: 277, anno: 1999,
pagine: E1122 - E1129
SICI:
0193-1849(199912)277:6<E1122:PIINEF>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
VAGAL NERVE-STIMULATION; SOMATOSTATIN SECRETION; ENDOCRINE PANCREAS; INDUCED INCREASE; DOG; POLYPEPTIDE; RELEASE; LIVER; ISLETS; STATE;
Keywords:
pancreas; nerves and hormones;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Coker, RH Univ Mississippi, Dept Exercise Sci, Turner Ctr 220, University,MS 38677 USA Univ Mississippi University MS USA 38677 iversity, MS 38677 USA
Citazione:
R.H. Coker et al., "Pancreatic innervation is not essential for exercise-induced changes in glucagon and insulin or glucose kinetics", AM J P-ENDO, 277(6), 1999, pp. E1122-E1129

Abstract

The purpose of this study was to determine the role of pancreatic innervation in mediating exercise-induced changes in pancreatic hormone secretion and glucose kinetics. Dogs underwent surgery >16 days before an experiment, at which time flow probes were implanted on the portal vein and the hepaticartery, and Silastic catheters were inserted in the carotid artery, portalvein, and hepatic vein for sampling. In one group of dogs (DP) all nerves and plexuses to the pancreas were sectioned during surgery. A second group of dogs underwent sham denervation (SHAM). Pancreatic tissue norepinephrinewas reduced by >98% in DP dogs. Each study consisted of basal (-30 to 0 min) and moderate exercise (0 to 150 min, 100 m/min, 12% grade) periods. Isotope ([3-H-3]glucose) dilution and arteriovenous differences were used to assess hepatic function. Arterial and portal vein glucagon and insulin concentrations and the rate of net extrahepatic splanchnic glucagon release (NESGR) were similar in DP and SHAM during the basal period. Arterial and portalvein glucagon and NESGR increased similarly in DP and SHAM during exercise. Arterial and portal vein insulin were similar during exercise. Arterial glucose, tracer-determined endogenous glucose production, and net hepatic glucose output were similar in DP and SHAM during the basal and exercise periods. These results demonstrate that pancreatic nerves are not essential to pancreatic hormone secretion or glucose homeostasis during rest or moderateexercise.

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Documento generato il 05/04/20 alle ore 07:04:28