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Titolo:
Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in human skeletal muscle
Autore:
Houmard, JA; Shaw, CD; Hickey, MS; Tanner, CJ;
Indirizzi:
E Carolina Univ, Human Performance Lab, Greenville, NC 27858 USA E Carolina Univ Greenville NC USA 27858 nce Lab, Greenville, NC 27858 USA E Carolina Univ, Dept Exercise & Sport Sci, Greenville, NC 27858 USA E Carolina Univ Greenville NC USA 27858 ort Sci, Greenville, NC 27858 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
fascicolo: 6, volume: 277, anno: 1999,
pagine: E1055 - E1060
SICI:
0193-1849(199912)277:6<E1055:EOSETO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR SUBSTRATE-1 PHOSPHORYLATION; GLUT-4 PROTEIN-CONTENT; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHOINOSITIDE 3-KINASE; DIFFERENTIAL REGULATION; GLUCOSE-TRANSPORT; IN-VIVO; NIDDM; PATHWAY; IRS-1;
Keywords:
insulin signaling; contractile activity; striated muscle; physical activity; phosphatidylinositol 3-kinase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Houmard, JA E Carolina Univ, Human Performance Lab, Ward Sports Med Bldg, Greenville, NC 27858 USA E Carolina Univ Ward Sports Med Bldg Greenville NCUSA 27858 A
Citazione:
J.A. Houmard et al., "Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in human skeletal muscle", AM J P-ENDO, 277(6), 1999, pp. E1055-E1060

Abstract

The purpose of this study was to determine if the improvement in insulin sensitivity with exercise training is associated with enhanced phosphatidylinositol 3-kinase (PI 3-kinase) activity. Nine sedentary men were studied before and after 7 days of exercise training (1 h/day, approximate to 75% maximal oxygen consumption). Insulin sensitivity was determined with a euglycemic-hyperinsulinemic glucose clamp in the sedentary state and 15-17 h afterthe final exercise bout. PI 3-kinase activity was determined from samples (vastus lateralis) obtained in the fasted condition and after 60 min of submaximal insulin stimulation during the clamp. After exercise, glucose infusion rate increased (P < 0.05) significantly (means +/- SE, 7.8 +/- 0.5 vs. 9.8 +/- 0.8 mg kg(-1) min(-1)), indicating improved insulin sensitivity. Insulin-stimulated (insulin stimulated/fasting) phosphotyrosine immunoprecipitable PI 5-kinase activity also increased significantly (P < 0.05) with exercise (3.1 +/- 0.1-fold) compared with the sedentary condition (1.3 +/- 0.1-fold). There was no change in fasting PI 3-kinase activity. These data suggest that an enhancement of insulin signal transduction in skeletal muscle may contribute to the improvement in insulin action with exercise.

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Documento generato il 03/12/20 alle ore 11:37:42