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Titolo:
Neuroendocrine modulation of the "menopause": insights into the aging brain
Autore:
Wise, PM;
Indirizzi:
Univ Kentucky, Coll Med, Dept Physiol, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 ept Physiol, Lexington, KY 40536 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
fascicolo: 6, volume: 277, anno: 1999,
pagine: E965 - E970
SICI:
0193-1849(199912)277:6<E965:NMOT"I>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-RELEASING HORMONE; MIDDLE-AGED RATS; FOLLICLE-STIMULATING-HORMONE; INDUCED LUTEINIZING-HORMONE; PITUITARY-OVARIAN FUNCTION; SUPRACHIASMATIC NUCLEUS; GENE-EXPRESSION; POSTMENOPAUSAL WOMEN; PROLACTIN SURGES; MENSTRUAL CYCLES;
Keywords:
estrogen; luteinizing hormone; gonadotropin-releasing hormone; menstrual cycle; circadian rhythm; neuroprotection;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Wise, PM Univ Kentucky, Coll Med, Dept Physiol, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 ol, Lexington, KY 40536 USA
Citazione:
P.M. Wise, "Neuroendocrine modulation of the "menopause": insights into the aging brain", AM J P-ENDO, 277(6), 1999, pp. E965-E970

Abstract

The menopause marks the permanent end of fertility in women. It was once thought that this dramatic physiological change could be explained simply bythe exhaustion of the reservoir of ovarian follicles. New data from studies performed in women and animal models make us reassess this assumption. Anincreasing body of evidence suggests that there are multiple pacemakers that contribute to the transition to irregular cycles, decreasing fertility, and the timing of the menopause. We will present evidence that lends credence to the possibility that a dampening and desynchronization of the precisely orchestrated neural signals lead to miscommunication between the brain and the pituitary-ovarian axis, and that this constellation of hypothalamic-pituitary-ovarian events leads to the deterioration of regular cyclicity and heralds menopausal transition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 16:58:55