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Titolo:
Role of protein phosphatases in the regulation of human mast cell and basophil function
Autore:
Peirce, MJ; Munday, MR; Peachell, PT;
Indirizzi:
Univ Sheffield, Sect Mol Pharmacol & Pharmacogenet, Sheffield S10 2JF, S Yorkshire, England Univ Sheffield Sheffield S Yorkshire England S10 2JF S Yorkshire, England Univ London, Sch Pharm, Dept Pharmaceut & Biol Chem, London WC1N 1AX, England Univ London London England WC1N 1AX Biol Chem, London WC1N 1AX, England
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
fascicolo: 6, volume: 277, anno: 1999,
pagine: C1021 - C1028
SICI:
0363-6143(199912)277:6<C1021:ROPPIT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD45 PHOSPHOTYROSINE PHOSPHATASE; IGE-MEDIATED STIMULATION; OKADAIC ACID-DERIVATIVES; COMMON ANTIGEN CD45; TYROSINE-PHOSPHATASE; HISTAMINE-RELEASE; CYCLOSPORINE-A; FC-EPSILON; SERINE/THREONINE PHOSPHATASES; SIGNAL-TRANSDUCTION;
Keywords:
okadaic acid; calyculin A; cyclosporin; FK506; dephosphorylation; histamine release;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
100
Recensione:
Indirizzi per estratti:
Indirizzo: Peachell, PT Univ Sheffield, Royal Hallamshire Hosp, Sect Mol Pharmacol & Pharmacogenet, Floor L,Glossop Rd, Sheffield S10 2JF, S Yorkshire, England Univ Sheffield Floor L,Glossop Rd Sheffield S Yorkshire England S10 2JF
Citazione:
M.J. Peirce et al., "Role of protein phosphatases in the regulation of human mast cell and basophil function", AM J P-CELL, 277(6), 1999, pp. C1021-C1028

Abstract

Many extracellular stimuli mediate physiological change in target cells byaltering the phosphorylation state of proteins. These alterations result from the dynamic interplay of protein kinases, which mediate phosphorylations, and protein phosphatases, which catalyse dephosphorylations. The antigen-mediated aggregation of high-affinity receptors for IgE on mast cells and basophils triggers rapid changes in the phosphorylation of many proteins and culminates in the generation of inflammatory mediators involved in allergic inflammatory diseases such as asthma. Although protein kinases have an established role in this process, less is known about the involvement of protein phosphatases. This imbalance has been redressed in recent years by theavailability of phosphatase inhibitors, such as okadaic acid, that facilitate investigations of the role of protein phosphatases in intact cells. Here we review a number of studies in which inhibitors of protein phosphataseshave been used to shed light on the potential importance of these enzymes in the regulation of human mast cell and human basophil function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:14:43