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Titolo:
Synthesis and properties of Biagra. A 5-(2,3-dihydro-7-benzofuryl) analog of Viagra((R))
Autore:
Voelter, W; El-Abadelah, MM; Sabri, SS; Khanfar, MA;
Indirizzi:
Univ Tubingen, Phys Biochem Abt, Inst Chem Phys, D-72076 Tubingen, GermanyUniv Tubingen Tubingen Germany D-72076 m Phys, D-72076 Tubingen, Germany Univ Jordan, Fac Sci, Dept Chem, Amman, Jordan Univ Jordan Amman JordanUniv Jordan, Fac Sci, Dept Chem, Amman, Jordan Univ Tubingen, Inst Anorgan Chem, D-72076 Tubingen, Germany Univ TubingenTubingen Germany D-72076 n Chem, D-72076 Tubingen, Germany
Titolo Testata:
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
fascicolo: 11, volume: 54, anno: 1999,
pagine: 1469 - 1473
SICI:
0932-0776(199911)54:11<1469:SAPOBA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYPE-5 CGMP PHOSPHODIESTERASE; MALE ERECTILE DYSFUNCTION; SILDENAFIL; PHYSIOLOGY; INHIBITOR;
Keywords:
dihydrobezofuryl-pyrazolo[4,3-d]pyrimidin Viagra((R)) analog; erectogenic activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Voelter, W Univ Tubingen, Phys Biochem Abt, Inst Chem Phys, Hoppe Seyler Str 4, D-72076 Tubingen, Germany Univ Tubingen Hoppe Seyler Str 4 Tubingen Germany D-72076 many
Citazione:
W. Voelter et al., "Synthesis and properties of Biagra. A 5-(2,3-dihydro-7-benzofuryl) analog of Viagra((R))", Z NATURFO B, 54(11), 1999, pp. 1469-1473

Abstract

The synthesis and spectral properties (IR, MS, NMR) of a substituted 5-(2,3-dihydro-7-benzofuryl)pyrazolo[4,3-d]pyrimidin-7-one (2); an analog of Viagra(R) (1), are described. The generally applicable route involves interaction of 2,3-dihydro-7-benzofuranoyl chloride (3) with 4-amino-1-methyl-3-propyl-5-pyrazolecarboxamide (4), and the resulting bis-amide (5) is cyclized to the corresponding substituted pyrazolo[4.3-d]pyrimidin-7-one (6). Chlorosulfonylation of 6, followed by treatment with l-methylpiperazine. furnished the title compound 2 (named Biagra). Preliminary experiments "associated with the erectile process" on rats lend evidence of greater potency of Biagra (2) as compared to Viagra(R) (1).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 23:31:25