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Titolo:
High prevalence of Borna disease virus in domestic cats with neurological disorders in Japan
Autore:
Nakamura, Y; Watanabe, M; Kamitani, W; Taniyama, H; Nakaya, T; Nishimura, Y; Tsujimoto, H; Machida, S; Ikuta, K;
Indirizzi:
Hokkaido Univ, Inst Immunol Sci, Sect Serol, Sapporo, Hokkaido 0600815, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600815 oro, Hokkaido 0600815, Japan Osaka Univ, Microbial Dis Res Inst, Dept Virol, Osaka 5650871, Japan OsakaUniv Osaka Japan 5650871 es Inst, Dept Virol, Osaka 5650871, Japan Rakuno Gakuen Univ, Sch Vet Med, Dept Pathol, Ebetsu, Hokkaido 0698501, Japan Rakuno Gakuen Univ Ebetsu Hokkaido Japan 0698501 Hokkaido 0698501, Japan Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Internal Med, Bunkyo Ku, Tokyo 1138657, Japan Univ Tokyo Tokyo Japan 1138657 rnal Med, Bunkyo Ku, Tokyo 1138657, Japan Machida Anim Hosp, Tokyo 1980032, Japan Machida Anim Hosp Tokyo Japan 1980032 da Anim Hosp, Tokyo 1980032, Japan
Titolo Testata:
VETERINARY MICROBIOLOGY
fascicolo: 3-4, volume: 70, anno: 1999,
pagine: 153 - 169
SICI:
0378-1135(199912)70:3-4<153:HPOBDV>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-BLOOD MONONUCLEAR; CENTRAL-NERVOUS-SYSTEM; FELINE NONSUPPURATIVE MENINGOENCEPHALOMYELITIS; NITRIC-OXIDE SYNTHASE; STAGGERING DISEASE; PSYCHIATRIC-PATIENTS; INTERFERON-GAMMA; CELLS; INFECTION; RNA;
Keywords:
Borna disease virus; cat; neurologic disorder; staggering disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Ikuta, K Hokkaido Univ, Inst Immunol Sci, Sect Serol, Sapporo, Hokkaido 0600815, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600815 aido 0600815, Japan
Citazione:
Y. Nakamura et al., "High prevalence of Borna disease virus in domestic cats with neurological disorders in Japan", VET MICROB, 70(3-4), 1999, pp. 153-169

Abstract

A total of 15 (T-1-T-15) domestic cats with neurological disorders in Tokyo area were examined for association with Borna disease virus (BDV), None had detectable antibodies to feline immunodeficiency virus (FIV), feline leukemia virus, feline infectious peritonitis virus and Toxoplasma gondii, andonly cat T-8 had detectable antibody to FIV. Serological and molecular epidemiological studies revealed a significantly high prevalence of BDV infection in these cats: antibodies against BDV p24 and/or p40 proteins in 10/15 (66.7%) and p24 and/or p40 RNA in peripheral blood mononuclear cells in 8/15 (53,3%), Further, in situ hybridization and immunohistochemistry analysesof the autopsied brain samples derived from one of the cats (T-15) revealed BDV RNA predominantly in neuronal cells in restricted regions, such as olfactory bulb and medulla of cerebrum. Thus, BDV is present in Japanese domestic cats with neurological disorders at a high prevalence. (C) 1999 Elsevier Science B,V, All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:22:38