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Titolo:
Monocyte tissue factor response is decreased in patients with hyperlipidemia
Autore:
Rugeri, L; Susen, S; Bard, JM; Corseaux, D; Gaveriaux, V; Devos, P; Lecerf, JM; Duriez, P; Jude, B;
Indirizzi:
Ctr Hosp Reg Univ, Hematol Lab, Lille, France Ctr Hosp Reg Univ Lille France osp Reg Univ, Hematol Lab, Lille, France Ctr Hosp Reg Univ, INSERM, U325, Lille, France Ctr Hosp Reg Univ Lille France sp Reg Univ, INSERM, U325, Lille, France Ctr Hosp Reg Univ, Ctr Rech Informat Med, Lille, France Ctr Hosp Reg UnivLille France iv, Ctr Rech Informat Med, Lille, France Ctr Hosp Reg Univ, Serv Med Interne, Lille, France Ctr Hosp Reg Univ Lille France eg Univ, Serv Med Interne, Lille, France Inst Pasteur, F-59019 Lille, France Inst Pasteur Lille France F-59019Inst Pasteur, F-59019 Lille, France
Titolo Testata:
THROMBOSIS RESEARCH
fascicolo: 4, volume: 96, anno: 1999,
pagine: 283 - 292
SICI:
0049-3848(19991115)96:4<283:MTFRID>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR PATHWAY INHIBITOR; TOTAL PARENTERAL-NUTRITION; PROCOAGULANT ACTIVITY; PLASMINOGEN-ACTIVATOR; LIPOPROTEIN PARTICLES; IMMUNOSORBENT-ASSAY; FACTOR EXPRESSION; ENDOTOXIN; PLASMA; SERUM;
Keywords:
tissue factor; monocyte; hyperlipidemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Jude, B Hop Cardiol, Hematol Lab, Blvd Prof J Leclercq, F-59037 Lille, France Hop Cardiol Blvd Prof J Leclercq Lille France F-59037 lle, France
Citazione:
L. Rugeri et al., "Monocyte tissue factor response is decreased in patients with hyperlipidemia", THROMB RES, 96(4), 1999, pp. 283-292

Abstract

Monocytes are potent regulators of blood coagulation through the expression of tissue factor (TF) on stimulation and of tissue factor pathway inhibitor (TFPI), a selective inhibitor of TF pathway. As hyperlipidemia can modify some monocyte functions, we compared the TF and TFPI expression by circulating monocytes and the plasma TFPI levels between 65 healthy normolipemic controls and 38 nontreated hyperlipemic patients. TF and TFPI relationshipswith plasma lipoproteins are also examined. TF and TFPI expression were evaluated in peripheral mononuclear cells after isolation from blood by density gradient centrifugation and after short culture with or without lipopolysaccharide (LPS). TF and TFPI activity and antigen were measured in mononuclear cell lysates using amidolytic assay and enzyme-linked immunosorbent assay, respectively. TFPI activity and antigen were measured in plasma using the same methods. Plasma factor VII (FVII) activity and antigen were also determined. LPS-stimulated monocyte TF activity and antigen were lower in hyperlipidemic patients than in controls (0.0001<p<0.03). This decrease of monocyte TF expression in hyperlipidemic patients was not related to an increase of monocyte TFPI. Monocyte TF activity was negatively correlated to atherogenic fractions and positively correlated to protective fractions, specially after ex vivo LPS stimulation. Increased TFPI and FVII plasma levels were found in hyperlipidemic patients compared to controls. These results indicate an impairment of TF production by circulating monocytes from hyperlipidemic subjects, which is linked to the increase of atherogenic lipoprotein fractions. Further studies are required to elucidate the mechanism of this inhibition. (C) 1999 Elsevier Science Ltd. All rights reserved.

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Documento generato il 26/09/20 alle ore 17:30:20