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Titolo:
Kinetic modeling of benzodiazepine receptor binding with PET and high specific activity [C-11]Iomazenil in healthy human subjects
Autore:
Bremner, JD; Horti, A; Staib, LH; Zea-Ponce, Y; Soufer, R; Charney, DS; Baldwin, R;
Indirizzi:
Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06250 USA Yale Univ New Haven CT USA 06250 Diagnost Radiol, New Haven, CT 06250 USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06250 USA Yale Univ New Haven CT USA 06250 , Dept Psychiat, New Haven, CT 06250 USA Yale VA PET Ctr, W Haven, CT 06250 USA Yale VA PET Ctr W Haven CT USA 06250 le VA PET Ctr, W Haven, CT 06250 USA VA Connecticut Healthcare Syst, Natl Ctr PTSD, New Haven, CT USA VA Connecticut Healthcare Syst New Haven CT USA PTSD, New Haven, CT USA NIDA, Brain Imaging Ctr, Intramural Res Program, Baltimore, MD 21224 USA NIDA Baltimore MD USA 21224 tramural Res Program, Baltimore, MD 21224 USA
Titolo Testata:
SYNAPSE
fascicolo: 1, volume: 35, anno: 2000,
pagine: 68 - 77
SICI:
0887-4476(200001)35:1<68:KMOBRB>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; HUMAN-BRAIN; C-11 FLUMAZENIL; I-123 IOMAZENIL; QUANTITATIVE-EVALUATION; COMPARTMENTAL ANALYSIS; SPECT MEASUREMENT; RO 15-1788; INVIVO; IODINE-123-IOMAZENIL;
Keywords:
PET; iomazenil; modeling; neuroimaging; benzodiazepines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Bremner, JD VA Connecticut Healthcare Syst, Yale VA PET Ctr 115A, 950 Campbell Ave, W Haven, CT 06516 USA VA Connecticut Healthcare Syst 950 CampbellAve W Haven CT USA 06516
Citazione:
J.D. Bremner et al., "Kinetic modeling of benzodiazepine receptor binding with PET and high specific activity [C-11]Iomazenil in healthy human subjects", SYNAPSE, 35(1), 2000, pp. 68-77

Abstract

Quantitation of the PET benzodiazepine receptor antagonist, [C-11]Iomazenil, using low specific activity radioligand was recently described. The purpose of this study was to quantitate benzodiazepine receptor binding in human subjects using PET and high specific activity [C-11]Iomazenil. Six healthy human subjects underwent PET imaging following a bolus injection of high specific activity (>100 Ci/mmol) [C-11]iomazenil. Arterial samples were collected at multiple time points after injection for measurement of unmetabolized total and nonprotein-bound parent compound in plasma. Time activity curves of radioligand concentration in brain and plasma were analyzed using two and three compartment model. Kinetic rate constants of transfer of radioligand between plasma, nonspecifically bound brain tissue, and specificallybound brain tissue compartments were fitted to the model. Values for fitted kinetic rate constants were used in the calculation of measures of benzodiazepine receptor binding, including binding potential (the ratio of receptor density to affinity), and product of BP and the fraction of free nonprotein-bound parent compound (V-3'). Use of the three compartment model improved the goodness of fit in comparison to the two compartment model. Values for kinetic rate constants and measures. of benzodiazepine receptor binding,including BP and V-3', were similar to results obtained with the SPECT radioligand [I-123]iomazenil, and a prior report with low specific activity [C-11]Iomazenil. Kinetic modeling using the three compartment model with PET and high specific activity [C-11]Iomazenil provides a reliable measure of benzodiazepine receptor binding. Synapse 35:68-77, 2000. Published 2000 Wiley-Liss, Inc.dagger

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:32:49