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Titolo:
Impact of primary surgery on outcome in 300 patients with pathologic tumor-node-metastasis stage III papillary thyroid carcinoma treated at one institution from 1940 through 1989
Autore:
Hay, ID; Bergstralh, EJ; Grant, CS; McIver, B; Thompson, GB; van Heerden, JA; Goellner, JR;
Indirizzi:
Mayo Clin & Med Ctr, Div Endocrinol & Internal Med, Dept Surg, Biostat Sect, Rochester, MN USA Mayo Clin & Med Ctr Rochester MN USA rg, Biostat Sect, Rochester, MN USA Mayo Clin & Med Ctr, Div Anat Pathol, Rochester, MN USA Mayo Clin & Med Ctr Rochester MN USA Div Anat Pathol, Rochester, MN USA
Titolo Testata:
SURGERY
fascicolo: 6, volume: 126, anno: 1999,
pagine: 1173 - 1181
SICI:
0039-6060(199912)126:6<1173:IOPSOO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGNOSTIC SCORING SYSTEM; RETROSPECTIVE ANALYSIS; CANCER; MANAGEMENT; SURVIVAL; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Hay, ID Mayo Clin & Mayo Fdn, Div Endocrinol, 200 1st St SW, Rochester, MN55905 USA Mayo Clin & Mayo Fdn 200 1st St SW Rochester MN USA 55905 5905 USA
Citazione:
I.D. Hay et al., "Impact of primary surgery on outcome in 300 patients with pathologic tumor-node-metastasis stage III papillary thyroid carcinoma treated at one institution from 1940 through 1989", SURGERY, 126(6), 1999, pp. 1173-1181

Abstract

Background. The pathologic tumor-node-metastasis (pTNM) system is universally used to define the extent of disease in human malignancies. This study evaluated the impact of initial therapy on cause-specific mortality (CSM) rates and recurrence rates in pTNM stage III papillary thyroid carcinoma. Methods. Three hundred patients (median age, 58 years) were followed on average for 14 postoperative years. Of these, 246 patients (82%) had completeprimary tumor resection; 208 patients (69%) had nodal metastases; 161 (54%) had locally invasive primary tumors; 45 patients (15%) underwent initial unilateral lobectomy (UL). Bilateral lobar resection (BLR) accounted for 242 patients (near-total, 54%; total thyroidectomy, 23%). Results. The 30-year rates for CSM, distant metastases, nodal metastases, and local recurrence (LR) were 29%, 22%, 19%, and 16%, respectively. The 20-year rates for CSM were significantly, higher (50% vs 14%) when primary tumor was incompletely resected (P = .0001). lifter complete resection, 20-year rates for CSM and LR after BLR were 12% and 10%, respectively, which were significantly lower (P < .05) than the 23% and 26% rates seen after UL. There were no significant differences in nodal metastases or distant metastases rates between UL and BLR (P > .4). The 20-year LR rate after total thyroidectomy (13%) was not different (P = .5) from the 11% seen after near-total thyroidectomy. Conclusions. In this nonrandomized evaluation of patients with pTNM stage III papillary thyroid carcinoma, the extent of primary thyroid resection appeared to significantly impact CSM and LR but did not apparently influence regional or distant metastasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:36:08