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Titolo:
Foregut carcinoids: A clinical and biochemical analysis
Autore:
Kirshbom, PM; Kherani, AR; Onaitis, MW; Hata, A; Kehoe, TE; Feldman, C; Feldman, JM; Tyler, DS;
Indirizzi:
Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 v, Med Ctr, Dept Surg, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Endocrinol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Ctr, Dept Endocrinol, Durham, NC 27710 USA
Titolo Testata:
SURGERY
fascicolo: 6, volume: 126, anno: 1999,
pagine: 1105 - 1110
SICI:
0039-6060(199912)126:6<1105:FCACAB>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMORS; SEROTONIN; PANCREAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Tyler, DS Duke Univ, Med Ctr, Dept Surg, POB 3118, Durham, NC 27710 USA Duke Univ POB 3118 Durham NC USA 27710 118, Durham, NC 27710 USA
Citazione:
P.M. Kirshbom et al., "Foregut carcinoids: A clinical and biochemical analysis", SURGERY, 126(6), 1999, pp. 1105-1110

Abstract

Background. Gastrointestinal foregut carcinoids make up a small percentage(3% to 6%) of all reported carcinoids. Because these tumors are so uncommon, comparisons between the subtypes have been difficult. The goal of this study was to compare the hormonal and clinical characteristics of gastric, duodenal, and pancreatic carcinoids. Methods. A prospective database of approximately 750 carcinoid patients seen by one author over 25 years was reviewed, and the 104 patients with gastric (33), duodenal (17), or pancreatic (54) carcinoids were selected as thesubgroup for analysis. These patients were compared with regard to hormonelevels, clinical course, treatment, and survival. Results. Duodenal carcinoids exhibited significantly lower serotoninergic hormone levels than did the gastric and pancreatic carcinoids (urine 5-hydroxyindoleacetic acid [mg/24 h], 5 +/- 1 vs 16 +/- 5 and 47 +/- 12, respectively, P = .03). Pancreatic carcinoids presented with more advanced stage (distant metastases 87% vs 42% and 20% for gastric and duodenal, respectively) and had worse outcomes than patients with gastric and duodenal tumors with 10-year survivals of 10%, 59%, and 58%, respectively (P = .003). Conclusions. Pancreatic carcinoids produce higher levels of serotoninergichormones and have a significantly higher stage and worse outcome than other foregut carcinoids. This study demonstrates that the organ of origin is an important determinant of hormonal activity and clinical course for patients with foregut carcinoids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 00:53:27