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Titolo:
ESTROGEN INHIBITS THE VASCULAR INJURY RESPONSE IN ESTROGEN-RECEPTOR ALPHA-DEFICIENT MICE
Autore:
IAFRATI MD; KARAS RH; ARONOVITZ M; KIM S; SULLIVAN TR; LUBAHN DB; ODONNELL TF; KORACH KS; MENDELSOHN ME;
Indirizzi:
TUFTS UNIV NEW ENGLAND MED CTR,MOL CARDIOL RES CTR,TUPPER RES INST,750 WASHINGTON ST BOSTON MA 02111 TUFTS UNIV NEW ENGLAND MED CTR,MOL CARDIOL RES CTR,TUPPER RES INST BOSTON MA 02111 UNIV MISSOURI,DEPT BIOCHEM COLUMBIA MO 65201 UNIV MISSOURI,DEPT CHILD HLTH COLUMBIA MO 65201 NIEHS,REPROD & DEV TOXICOL LAB,NIH RES TRIANGLE PK NC 27709
Titolo Testata:
Nature medicine
fascicolo: 5, volume: 3, anno: 1997,
pagine: 545 - 548
SICI:
1078-8956(1997)3:5<545:EITVIR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; ATHEROSCLEROTIC CORONARY-ARTERIES; NITRIC-OXIDE; MOUSE; EXPRESSION; ESTRADIOL; GENE; 17-BETA-ESTRADIOL; TRANSCRIPTION; ENDOTHELIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
M.D. Iafrati et al., "ESTROGEN INHIBITS THE VASCULAR INJURY RESPONSE IN ESTROGEN-RECEPTOR ALPHA-DEFICIENT MICE", Nature medicine, 3(5), 1997, pp. 545-548

Abstract

The atheroprotective effects of estrogen in women are well recognized(1), but the underlying mechanisms responsible are not well understood. Blood vessel cells express the classic estrogen receptor, ER alpha (ref. 2-6), and are directly affected by estrogen, which inhibits the development of atherosclerotic and injury-induced vascular lesions(7,8). We have generated mice in which the ER alpha gene is disrupted(9) and have used a mouse model of carotid arterial injury to compare the effects of estrogen on wild-type and estrogen receptor-deficient mice. Increases in vascular medial area and smooth muscle cell proliferation were quantified following vascular injury in ovariectomized mice treated with vehicle or with physiologic levels of 17 beta-estradiol. Suprisingly, in both wild-type and estrogen receptor-deficient mice, 17 beta-estradiol markedly inhibited to the same degree all measures of vascular injury. These data demonstrate that estrogen inhibits vascular injury by a novel mechanism that is independent of the classic estrogen receptor, ER alpha.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/10/20 alle ore 10:36:49