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Titolo:
Serotonin and the prediction of response time to fluoxetine in patients with mild depression
Autore:
New, AS; Woo-Ming, A; Mitropoulou, V; Silverman, J; Reynolds, D; Schopick, F; Trestman, RL; Siever, LJ;
Indirizzi:
Mt Sinai Sch Med, Dept Psychiat, Bronx, NY 10468 USA Mt Sinai Sch Med Bronx NY USA 10468 d, Dept Psychiat, Bronx, NY 10468 USA Vet Affairs Med Ctr, Bronx, NY 10468 USA Vet Affairs Med Ctr Bronx NY USA10468 fairs Med Ctr, Bronx, NY 10468 USA
Titolo Testata:
PSYCHIATRY RESEARCH
fascicolo: 2, volume: 88, anno: 1999,
pagine: 89 - 93
SICI:
0165-1781(19991108)88:2<89:SATPOR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
FENFLURAMINE CHALLENGE TEST; MAJOR DEPRESSION; REUPTAKE INHIBITORS; INPATIENTS;
Keywords:
fenfluramine; prolactin; Hamilton Depression Rating Scale;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: New, AS Mt Sinai Sch Med, Dept Psychiat, 116A,130 W Kingsbridge, Bronx, NY10468 USA Mt Sinai Sch Med 116A,130 W Kingsbridge Bronx NY USA 10468 468 USA
Citazione:
A.S. New et al., "Serotonin and the prediction of response time to fluoxetine in patients with mild depression", PSYCHIAT R, 88(2), 1999, pp. 89-93

Abstract

Serotonin (5-HT) dysregulation has been associated with major depressive disorder (MDD); a blunted prolactin (PRL) response to D,L-fenfluramine (FEN)has been associated with MDD. Pharmacologic manipulation of the serotonin system with a selective serotonin reuptake inhibitor (SSRI) is effective inthe treatment of depression. However, the relationship between pre-treatment 5-HT activity and response to SSRIs is not well understood. This study investigated the relationship between 5-HT dysregulation and response to fluoxetine (FLU). Twenty patients with MDD entered a double-blind placebo-controlled trial of fluoxetine preceded by D,L-fenfluramine stimulation. Patients were assigned randomly to either FLU, 20 mg QD, or placebo (PLA) for an 11-week trial. No relationship was found between the PRL response to FEN and response to FLU. Among the seven responding to FLU, there was a significant negative correlation between PRL response and the time until sustained response to FLU (r = -0.93, P < 0.001, n = 7). Although preliminary, this study suggests that low baseline serotonin activity may be associated with a slower response to FLU in depression. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:20:24