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Titolo:
LACK OF EVIDENCE FOR ALLELIC ASSOCIATION BETWEEN PERSONALITY-TRAITS AND THE DOPAMINE D-4 RECEPTOR GENE POLYMORPHISMS
Autore:
JONSSON EG; NOTHEN MM; GUSTAVSSON JP; NEIDT H; BRENE S; TYLEC A; PROPPING P; SEDVALL GC;
Indirizzi:
KAROLINSKA INST,DEPT CLIN NEUROSCI,PSYCHIAT SECT S-17176 STOCKHOLM SWEDEN UNIV BONN,INST HUMAN GENET D-5300 BONN GERMANY
Titolo Testata:
The American journal of psychiatry
fascicolo: 5, volume: 154, anno: 1997,
pagine: 697 - 699
SICI:
0002-953X(1997)154:5<697:LOEFAA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPERAMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
E.G. Jonsson et al., "LACK OF EVIDENCE FOR ALLELIC ASSOCIATION BETWEEN PERSONALITY-TRAITS AND THE DOPAMINE D-4 RECEPTOR GENE POLYMORPHISMS", The American journal of psychiatry, 154(5), 1997, pp. 697-699

Abstract

Objective: Personality traits in human subjects have shown considerable heritable components. Recently, two research groups reported associations between dopamine D-4 receptor genotypes and the personality trait known as novelty seeking. This study was an attempt to replicate these findings. Method: Three different exonic dopamine D-4 receptor polymorphisms were genotyped in 126 healthy Swedish subjects. Personalitytraits of the subjects were assessed with the Karolinska Scales of Personality. Results: Although there was a tendency in the direction hypothesized, no significant association between genotype constellations and personality traits was found. Conclusions: The previously reportedassociation between dopamine D-4 receptor alleles and novelty seekingwas not replicated. Possible reasons for this include differences in personality inventories, ethnicity, and type I or type II errors.

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Documento generato il 26/01/20 alle ore 01:08:14