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Titolo:
Suppression of immediate-type hypersensitivity elicitation in the skin prick test by ultraviolet B irradiation
Autore:
Vocks, E; Stander, K; Rakoski, J; Ring, J;
Indirizzi:
Tech Univ Munich, Dept Dermatol & Allergol Biederstein, D-80802 Munich, Germany Tech Univ Munich Munich Germany D-80802 erstein, D-80802 Munich, Germany
Titolo Testata:
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
fascicolo: 6, volume: 15, anno: 1999,
pagine: 236 - 240
SICI:
0905-4383(199912)15:6<236:SOIHEI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARACHIDONIC-ACID; MAST-CELLS; HISTAMINE; PROTOPORPHYRIN;
Keywords:
ultraviolet irradiation; sun; skin prick test; immediate type hypersensitivity; photoimmunology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Vocks, E Tech Univ Munich, Dept Dermatol & Allergol Biederstein, Biedersteinerstr 29, D-80802 Munich, Germany Tech Univ Munich Biedersteinerstr 29 Munich Germany D-80802 many
Citazione:
E. Vocks et al., "Suppression of immediate-type hypersensitivity elicitation in the skin prick test by ultraviolet B irradiation", PHOTODERM P, 15(6), 1999, pp. 236-240

Abstract

Reproducibility of skin prick testing (SPT) and its modulation by ultraviolet B (UVB) radiation is of clinical interest. Sensitized atopic volunteers(groups A and B, n=21) were prick tested with common commercial allergen solutions (undiluted, diluted 1:10 and diluted 1:100) before, 24 h after oneand 24 h after three suberythematous UVB irradiations. Volunteers in groupA (n=8) received local UVB irradiation of prick test areas, whereas volunteers in group B (n=13) received whole body UVB irradiation, with prick testareas covered. In group A, the wheal intensities, expressed as the ratio allergen wheal size to histamine wheal size, were decreased by 28% (1:10 dilution) (P=0.01) and 45% (1:100 dilution) (P=0.02) after one UVB irradiation. Flare intensities were decreased by 48% (1:10 dilution) (P=0.03) after three UVB irradiations. In group B, the wheal and flare responses tended to decrease. Possible mechanisms of this short-term suppressive effect of UVB irradiation on SPT reactions include a direct effect on mast cells. It is concluded that UV irradiation, even a single exposure, prior to skin testing may compromise the validity of SPT testing.

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Documento generato il 26/01/21 alle ore 04:46:49