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Titolo: Suppression of immediate-type hypersensitivity elicitation in the skin prick test by ultraviolet B irradiation
Autore: Vocks, E; Stander, K; Rakoski, J; Ring, J;
- Indirizzi:
- Tech Univ Munich, Dept Dermatol & Allergol Biederstein, D-80802 Munich, Germany Tech Univ Munich Munich Germany D-80802 erstein, D-80802 Munich, Germany
- Titolo Testata:
- PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
fascicolo: 6,
volume: 15,
anno: 1999,
pagine: 236 - 240
- SICI:
- 0905-4383(199912)15:6<236:SOIHEI>2.0.ZU;2-C
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- ARACHIDONIC-ACID; MAST-CELLS; HISTAMINE; PROTOPORPHYRIN;
- Keywords:
- ultraviolet irradiation; sun; skin prick test; immediate type hypersensitivity; photoimmunology;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Clinical Medicine
- Citazioni:
- 13
- Recensione:
- Indirizzi per estratti:
- Indirizzo: Vocks, E Tech Univ Munich, Dept Dermatol & Allergol Biederstein, Biedersteinerstr 29, D-80802 Munich, Germany Tech Univ Munich Biedersteinerstr 29 Munich Germany D-80802 many
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- Citazione:
- E. Vocks et al., "Suppression of immediate-type hypersensitivity elicitation in the skin prick test by ultraviolet B irradiation", PHOTODERM P, 15(6), 1999, pp. 236-240
Abstract
Reproducibility of skin prick testing (SPT) and its modulation by ultraviolet B (UVB) radiation is of clinical interest. Sensitized atopic volunteers(groups A and B, n=21) were prick tested with common commercial allergen solutions (undiluted, diluted 1:10 and diluted 1:100) before, 24 h after oneand 24 h after three suberythematous UVB irradiations. Volunteers in groupA (n=8) received local UVB irradiation of prick test areas, whereas volunteers in group B (n=13) received whole body UVB irradiation, with prick testareas covered. In group A, the wheal intensities, expressed as the ratio allergen wheal size to histamine wheal size, were decreased by 28% (1:10 dilution) (P=0.01) and 45% (1:100 dilution) (P=0.02) after one UVB irradiation. Flare intensities were decreased by 48% (1:10 dilution) (P=0.03) after three UVB irradiations. In group B, the wheal and flare responses tended to decrease. Possible mechanisms of this short-term suppressive effect of UVB irradiation on SPT reactions include a direct effect on mast cells. It is concluded that UV irradiation, even a single exposure, prior to skin testing may compromise the validity of SPT testing.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 04:46:49