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Titolo:
Role of UVA in the pathogenesis of melanoma and non-melanoma skin cancer -A short review
Autore:
Runger, TM;
Indirizzi:
Boston Univ, Sch Med, Dept Dermatol, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 Med, Dept Dermatol, Boston, MA 02118 USA
Titolo Testata:
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
fascicolo: 6, volume: 15, anno: 1999,
pagine: 212 - 216
SICI:
0905-4383(199912)15:6<212:ROUITP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASAL-CELL CARCINOMA; OXIDATIVE DNA-DAMAGE; XERODERMA-PIGMENTOSUM; CUTANEOUS MELANOMA; MALIGNANT-MELANOMA; WAVELENGTH DEPENDENCE; EXCISION-REPAIR; SINGLET OXYGEN; HAIRLESS MICE; ULTRAVIOLET-B;
Keywords:
ultraviolet light; UVA; melanoma; non-melanoma skin cancer; oxidative DNA damage;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Runger, TM Boston Univ, Sch Med, Dept Dermatol, 609 Albany St, Boston, MA 02118 USA Boston Univ 609 Albany St Boston MA USA 02118 ton, MA 02118 USA
Citazione:
T.M. Runger, "Role of UVA in the pathogenesis of melanoma and non-melanoma skin cancer -A short review", PHOTODERM P, 15(6), 1999, pp. 212-216

Abstract

It is well established, at least in mice, that not only ultraviolet C (UVC) or ultraviolet B (UVB), but also ultraviolet A (UVA) is able to induce squamous cell carcinomas. Results from animal models, epidemiological studies, and clinical observations suggest that UVA might play an important role in the pathogenesis of malignant melanoma as well. In contrast to UVC or WE,UVA is hardly able to excite the DNA molecule directly and produces only few pyrimidine dimers. Oxidative DNA base damage, generated indirectly through photosensitizers, might be responsible for the mutagenic and carcinogenic properties of UVA. This is supported by differences in mutation spectra induced by UVA and UVB in mammalian cells and tumors. Avoidance of natural and artificial UVA sources is recommended, especially for melanoma-prone individuals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:38:32