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Titolo:
Pharmacokinetic interaction between ketoconazole and amprenavir after single doses in healthy men
Autore:
Polk, RE; Crouch, MA; Israel, DS; Pastor, A; Sadler, BM; Chittick, GE; Symonds, WT; Gouldin, W; Lou, Y;
Indirizzi:
Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharm, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA Roche Labs Inc, Nutley, NJ USA Roche Labs Inc Nutley NJ USARoche Labs Inc, Nutley, NJ USA Glaxo Wellcome Inc, Res Triangle Pk, NC 27709 USA Glaxo Wellcome Inc Res Triangle Pk NC USA 27709 Triangle Pk, NC 27709 USA Triangle Pharmaceut Inc, Durham, NC USA Triangle Pharmaceut Inc Durham NCUSA gle Pharmaceut Inc, Durham, NC USA
Titolo Testata:
PHARMACOTHERAPY
fascicolo: 12, volume: 19, anno: 1999,
pagine: 1378 - 1384
SICI:
0277-0008(199912)19:12<1378:PIBKAA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERYTHROMYCIN BREATH TEST; HIV-PROTEASE INHIBITORS; IN-VITRO; P-GLYCOPROTEIN; DRUG-INTERACTIONS; CELLS; METABOLISM; MIDAZOLAM; VX-478;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Polk, RE Box 980533 MCV, Richmond, VA 23298 USA Box 980533 MCV Richmond VA USA 23298 MCV, Richmond, VA 23298 USA
Citazione:
R.E. Polk et al., "Pharmacokinetic interaction between ketoconazole and amprenavir after single doses in healthy men", PHARMACOTHE, 19(12), 1999, pp. 1378-1384

Abstract

Study Objective. To determine the effects of coadministration of amprenavir and ketoconazole on the pharmacokinetics of both drugs, and to assess theutility of the erythromycin breath test (ERMBT) to predict and explain these effects. Design. Open-label, randomized, balanced, single-dose, three-period crossover study. Setting. University research centerSubjects. Twelve healthy men. Intervention. Subjects received amprenavir 1200 mg, ketoconazole 400 mg, and amprenavir 1200 mg plus ketoconazole 400 mg. Each treatment was separated by 14 days. Measurements and Main Results. Serial plasma samples for amprenavir and ketoconazole concentrations were measured by high-performance liquid chromatography. Coadministration of the drugs increased amprenavir area under the curve extrapolated to infinity (AUC(infinity)) by 31% and reduced its maximum concentration (C-max) by 16%. Amprenavir increased the AUG, of ketoconazole by 44% and increased the drug's half-life and C-max by 23% and 19%, respectively. Both agents resulted in substantial inhibition of ERMBT. Conclusion. Coadministration of ketoconazole and amprenavir results in a statistically significant increase in AUC for both agents, but the changes are not likely to be clinically important.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:03:46