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Titolo:
Citalopram: an interaction study with clomipramine in a patient heterozygous for CYP2D6 genotype
Autore:
Haffen, E; Vandel, P; Broly, F; Vandel, S; Sechter, D; Bizouard, P; Bechtel, PR;
Indirizzi:
Univ Hosp Besancon, Dept Clin Psychiat & Med Psychol, Besancon, France Univ Hosp Besancon Besancon France hiat & Med Psychol, Besancon, France Univ Hosp Besancon, Dept Clin Pharmacol, Besancon, France Univ Hosp Besancon Besancon France ept Clin Pharmacol, Besancon, France Univ Hosp Lille, Biochem & Mol Biol Lab, Lille, France Univ Hosp Lille Lille France lle, Biochem & Mol Biol Lab, Lille, France
Titolo Testata:
PHARMACOPSYCHIATRY
fascicolo: 6, volume: 32, anno: 1999,
pagine: 232 - 234
SICI:
0176-3679(199911)32:6<232:CAISWC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; MEPHENYTOIN OXIDATION POLYMORPHISMS; HUMAN LIVER-MICROSOMES; CONCOMITANT TREATMENT; PHARMACOKINETICS; DEXTROMETHORPHAN; SPARTEINE; PLASMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Haffen, E CHU Besancon, Serv Psychiat & Psychol Med, F-25030 Besancon, France CHU Besancon Besancon France F-25030 F-25030 Besancon, France
Citazione:
E. Haffen et al., "Citalopram: an interaction study with clomipramine in a patient heterozygous for CYP2D6 genotype", PHARMACOPS, 32(6), 1999, pp. 232-234

Abstract

A pharmacokinetic interaction between the selective serotonin reuptake inhibitor citalopram and a tricyclic antidepressant, clomipramine, was noted in a patient treated for major depression and obsessive-compulsive disorder. After the addition of citalopram, a desmethylclomipramine plasma level increase and an 8-hydroacy-desmethylclomipramine plasma level decrease were observed. The CYP2D6 phenotype, determined when the patient received the antidepressant comedication, characterized a poor metabolizer status (dextromethorphan metabolic ratio > 0.3), despite a heterozygous genotype containing a wild-type allele with extensive metabolic capacity and a mutant non-functional allele (CYP2D6*1A/CYP2D6*4A). This case seems to be one of the first descriptions of the clinical relevance of a CYP2D6 heterozygous genotype ina patient treated with antidepressant.

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Documento generato il 27/01/20 alle ore 07:28:23