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Titolo:
Sex-dependent behavioral effects of the neurosteroid allopregnanolone (3 alpha,5 alpha-THP) in neonatal and adult rats after postnatal stress
Autore:
Zimmerberg, B; Rackow, SH; George-Friedman, KP;
Indirizzi:
Williams Coll, Bronfman Sci Ctr, Dept Psychol, Williamstown, MA 01267 USA Williams Coll Williamstown MA USA 01267 ychol, Williamstown, MA 01267 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 4, volume: 64, anno: 1999,
pagine: 717 - 724
SICI:
0091-3057(199912)64:4<717:SBEOTN>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; GABA(A) RECEPTOR; MATERNAL-DEPRIVATION; ULTRASONIC VOCALIZATIONS; GENE-EXPRESSION; INFANT RATS; A RECEPTOR; RESPONSES; SEPARATION; CONSEQUENCES;
Keywords:
3 alpha,5 alpha-THP; allopreganolone; neurosteroid; stress; ultrasonic vocalization; grooming; sex; maternal separation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Zimmerberg, B Williams Coll, Bronfman Sci Ctr, Dept Psychol, Williamstown,MA 01267 USA Williams Coll Williamstown MA USA 01267 stown, MA 01267 USA
Citazione:
B. Zimmerberg et al., "Sex-dependent behavioral effects of the neurosteroid allopregnanolone (3 alpha,5 alpha-THP) in neonatal and adult rats after postnatal stress", PHARM BIO B, 64(4), 1999, pp. 717-724

Abstract

The neuroactive steroid allopregnanolone (3a-hydroxy-5a-pregnan-20-one, 3 alpha,5 alpha-THP) has been shown to be involved in the central nervous system's response to stress. This experiment investigated whether response to the neuroactive steroid allopregnanolone, a positive modulator of the GABA(A) receptor, would be altered in neonatal or adult rats previously exposed to a chronic stressor-daily maternal separation during the first week of life. Subjects were then tested either as neonates or adults. In neonates, allopregnanolone decreased the number of ultrasonic vocalizations after briefmaternal separation. Previously separated subjects vocalized less and wereless active than controls, but were not more sensitive to allopregnanoloneon either measure. In adulthood, subjects with a prior history of maternalseparation had a greater grooming response to a novel environment after a 10-min cold water swim test than nonseparated subjects. Allopregnanolone reduced grooming, but, again, there was no difference due to stress history. A significant effect of gender was noted in the adult subjects-females werelargely responsible for the effects reported. These results suggest that early maternal separation stress can produce an habituation response in neonates and a long-term sensitization response to later novel stress in adults. However, because the behavioral effects of allopregnanolone were not differentially influenced by this early stress history, the neuroactive steroid/GABA(A) receptor complex may not be the major mediator of these early stress sequela. Results indicating that females were more responsive to allopregnanolone than males are discussed in light of previous findings. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 05:56:46