Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The maternal separation paradigm and adult emotionality and cognition in male and female Wistar rats
Autore:
Lehmann, J; Pryce, CR; Bettschen, D; Feldon, J;
Indirizzi:
Swiss Fed Inst Technol, Behav Biol Lab, CH-8603 Schwerzenbach, SwitzerlandSwiss Fed Inst Technol Schwerzenbach Switzerland CH-8603 ch, Switzerland
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 4, volume: 64, anno: 1999,
pagine: 705 - 715
SICI:
0091-3057(199912)64:4<705:TMSPAA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; LITTER GENDER COMPOSITION; LATENT INHIBITION; SEX-DIFFERENCES; ACTIVE-AVOIDANCE; EARLY EXPERIENCE; PRENATAL STRESS; NEONATAL RAT; INFANT RAT; DEPRIVATION;
Keywords:
maternal separation; sex differences; open field; elevated plus-maze; conditioned freezing; active avoidance; water maze; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Feldon, J Swiss Fed Inst Technol, Behav Biol Lab, Schorenstr 16, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schorenstr 16 Schwerzenbach Switzerland CH-8603
Citazione:
J. Lehmann et al., "The maternal separation paradigm and adult emotionality and cognition in male and female Wistar rats", PHARM BIO B, 64(4), 1999, pp. 705-715

Abstract

A single 24-h maternal separation (MS) in the rat during the stress hyporesponsive period alters adult behavior and neuroendocrine stress response. The age of the animal at MS might be a crucial factor for effects in adulthood. We report here on adult behavioral effects of MS performed on postnatalday 4 (MS4), 9 (MS9), or 18 (MS18) in male and female Wistar rats. Unrelated subjects were used to avoid confounding litter effects. Subjects were tested on paradigms of unconditioned fear/anxiety, i.e., open field and elevated plus-maze, and on paradigms involving learning in an aversive situation, i.e., conditioned freezing, active avoidance, and water maze. In line with our predictions we obtained (a) sex differences that were consistent withenhanced fear/anxiety in males relative to females, (b) evidence that MS4 yielded deficits in active avoidance learning and conditioned freezing (trend level), whereas MS9 yielded enhanced active avoidance and water maze learning, (c) evidence (at trend level) that these effects of MS are greater in males than in females. There was no evidence for an effect of MS on paradigms of unconditioned fear/anxiety. We conclude that MS, irrespective of the age at separation, does not provide a robust environmental model of modified behavior in aversive situations. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 17:48:42