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Titolo:
Clozapine serum concentrations are lower in smoking than in non-smoking schizophrenic patients
Autore:
Seppala, NH; Leinonen, EVJ; Lehtonen, ML; Kivisto, KT;
Indirizzi:
Tampere Univ Hosp, Dept Clin Psychiat, Tampere, Finland Tampere Univ HospTampere Finland Dept Clin Psychiat, Tampere, Finland Tampere Univ Hosp, Dept Psychogeriatr, Tampere, Finland Tampere Univ HospTampere Finland Dept Psychogeriatr, Tampere, Finland Univ Tampere, Dept Clin Med, FIN-33101 Tampere, Finland Univ Tampere Tampere Finland FIN-33101 n Med, FIN-33101 Tampere, Finland Univ Helsinki, Dept Clin Pharmacol, SF-00250 Helsinki, Finland Univ Helsinki Helsinki Finland SF-00250 acol, SF-00250 Helsinki, Finland
Titolo Testata:
PHARMACOLOGY & TOXICOLOGY
fascicolo: 5, volume: 85, anno: 1999,
pagine: 244 - 246
SICI:
0901-9928(199911)85:5<244:CSCALI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; SEROTONIN REUPTAKE INHIBITORS; N-DESMETHYLCLOZAPINE; PLASMA-LEVELS; METABOLISM; PHARMACOKINETICS; PHARMACODYNAMICS; CYP1A2; CYP3A4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Seppala, NH Tampere Community Mental Hlth Ctr, Rautatienkatu 10, FIN-33100Tampere, Finland Tampere Community Mental Hlth Ctr Rautatienkatu 10 Tampere Finland FIN-33100
Citazione:
N.H. Seppala et al., "Clozapine serum concentrations are lower in smoking than in non-smoking schizophrenic patients", PHARM TOX, 85(5), 1999, pp. 244-246

Abstract

Serum concentrations of clozapine and its main metabolite demethylclozapine were measured in 44 schizophrenic inpatients, of whom ten were non-smokers and 34 smokers. When comparing their clozapine dose and body weight-related serum drug levels, we found that clozapine and demethylclozapine concentrations were about 40% lower in the smoking than in the non-smoking group, probably due to an inducing effect of smoking on the cytochrome P450 (CTP) 1A2, which is involved in the metabolism of clozapine. We conclude that dosage adjustment may be necessary in clozapine-treated smokers.

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Documento generato il 20/01/20 alle ore 16:00:38