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Titolo:
Oligodendroglioma: An appraisal of recent data pertaining to diagnosis andtreatment
Autore:
Fortin, D; Cairncross, GJ; Hammond, RR;
Indirizzi:
Oregon Hlth Sci Univ, Dept Neurol & Neurosurg, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 rosurg, Portland, OR 97201 USA Univ Western Ontario, Dept Clin Neurol Sci, London, ON, Canada Univ Western Ontario London ON Canada lin Neurol Sci, London, ON, Canada Univ Western Ontario, Dept Oncol, London, ON, Canada Univ Western OntarioLondon ON Canada io, Dept Oncol, London, ON, Canada Univ Western Ontario, Dept Pathol, London, ON, Canada Univ Western Ontario London ON Canada o, Dept Pathol, London, ON, Canada London Reg Canc Ctr, London, ON N6A 4L6, Canada London Reg Canc Ctr London ON Canada N6A 4L6 , London, ON N6A 4L6, Canada
Titolo Testata:
NEUROSURGERY
fascicolo: 6, volume: 45, anno: 1999,
pagine: 1279 - 1291
SICI:
0148-396X(199912)45:6<1279:OAAORD>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-GRADE GLIOMA; RECURRENT MALIGNANT OLIGODENDROGLIOMA; FIBRILLARY ACIDIC PROTEIN; KI-67 LABELING INDEXES; PROGNOSTIC FACTORS; RADIATION-THERAPY; ANAPLASTIC GLIOMAS; CEREBRAL HEMISPHERES; SURGICAL RESECTION; AGGRESSIVE OLIGODENDROGLIOMA;
Keywords:
chemotherapy; grading; histology; oligodendroglioma; radiotherapy; resection extent;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
120
Recensione:
Indirizzi per estratti:
Indirizzo: Fortin, D Ctr Univ Sante Estrie, Dept Neurosurg & Neurooncol, 3001 13E AveNord, Sherbrooke, PQ J1H 5N4, Canada Ctr Univ Sante Estrie 3001 13E Ave Nord Sherbrooke PQ Canada J1H 5N4
Citazione:
D. Fortin et al., "Oligodendroglioma: An appraisal of recent data pertaining to diagnosis andtreatment", NEUROSURGER, 45(6), 1999, pp. 1279-1291

Abstract

OBJECTIVE: This article reviews and summarizes recent data on the diagnosis, prognosis, and treatment of oligodendroglial tumors. METHODS: Histological criteria for optimized diagnosis and grading of oligodendroglial tumors are described and discussed. The therapeutic approachesare analyzed in light of the results of recent series. RESULTS: Oligodendroglial tumors may be more common than is generally thought. Perinuclear halo and "chicken-wire" pattern, although considered classic histological features of oligodendrogliomas, are unreliable as sole criteria for diagnosis. Nuclear regularity and roundness and an eccentric rim of eosinophilic cytoplasm lacking obvious cell processes are more constant features. Grading should be accomplished using a composite of radiological and histopathological relevant features. The allelic loss of chromosome arms1p and 19q might be a marker for both chemosensitivity and longer survivalafter chemotherapy. Oligodendrogliomas are notably chemosensitive when compared with other gliomas. For aggressive lesions, chemotherapy should be used upfront, after surgery. CONCLUSION: Oligodendrogliomas are underdiagnosed. One unfortunate implication is that a large number of patients may be receiving suboptimal care. Asimplification in grading of oligodendroglioma to two grades would reduce the confusion surrounding the classification and better define prognosis and response to treatment modalities. A better definition of the so-called mixed tumor should also allow a better classification of these lesions in an intermediate prognostic class between astrocytic and oligodendroglial lesions. Loss of 1p and 19q could be used as a cytogenetic marker in assisting grading. New concepts emerging in the recent literature should help optimizethe diagnosis of these lesions and reduce interobserver variability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:54:04