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Titolo:
Effect of insulin-like growth factor-I on growth hormone-releasing factor receptor expression in primary rat anterior pituitary cell culture
Autore:
Sugihara, H; Emoto, N; Tamura, H; Kamegai, J; Shibasaki, T; Minami, S; Wakabayashi, I;
Indirizzi:
Nippon Med Sch, Dept Med, Bunkyo Ku, Tokyo 1138603, Japan Nippon Med Sch Tokyo Japan 1138603 Med, Bunkyo Ku, Tokyo 1138603, Japan Nippon Med Sch, Dept Physiol, Bunkyo Ku, Tokyo 1138603, Japan Nippon Med Sch Tokyo Japan 1138603 siol, Bunkyo Ku, Tokyo 1138603, Japan Nippon Med Sch, Inst Gerontol, Nakahara Ku, Kanagawa 2118533, Japan NipponMed Sch Kanagawa Japan 2118533 kahara Ku, Kanagawa 2118533, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 276, anno: 1999,
pagine: 87 - 90
SICI:
0304-3940(199912)276:2<87:EOIGFO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RIBONUCLEIC-ACID; HYPOTHALAMUS; SUPPRESSION; GENE;
Keywords:
growth hormone; GH-releasing factor; GRF receptor; insulin-like growth factor-I; rat pituitary;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Sugihara, H Nippon Med Sch, Dept Med, Bunkyo Ku, Sendagi 1-1-5, Tokyo 1138603, Japan Nippon Med Sch Sendagi 1-1-5 Tokyo Japan 1138603 38603, Japan
Citazione:
H. Sugihara et al., "Effect of insulin-like growth factor-I on growth hormone-releasing factor receptor expression in primary rat anterior pituitary cell culture", NEUROSCI L, 276(2), 1999, pp. 87-90

Abstract

We examined the effect of insulin-like growth factor-I (IGF-I) on GH-releasing factor (GRF) receptor expression in the primary rat anterior pituitarycell culture. The levels of GRF receptor mRNA were dose-dependently reduced by IGF-I treatment for 24 h. To clarify whether altered levels of GRF receptor mRNA contribute to GRF receptor concentrations, we examined the GH response to GRF in vitro. There was no difference in basal GH secretion between control and IGF-I pretreated cells, while GRF-stimulated GH secretion incells pretreated with IGF-I for 24 h was significantly lower than that in control cells. Moreover, specific [I-125] Tyr(10)-human GRF binding to pituitary cells was reduced significantly by IGF-I treatment. These results suggest that IGF-I acts directly on the pituitary a nd participates in the regulation of GRF receptor expression. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 23:42:54