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Titolo:
The role of striatal adenosine A(2A) receptors in regulation of the muscletone in rats
Autore:
Wardas, J; Konieczny, J; Lorenc-Koci, E;
Indirizzi:
Polish Acad Sci, Inst Pharmacol, Dept Neuropsychopharmacol, PL-31343 Krakow, Poland Polish Acad Sci Krakow Poland PL-31343 harmacol, PL-31343 Krakow, Poland
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 276, anno: 1999,
pagine: 79 - 82
SICI:
0304-3940(199912)276:2<79:TROSAA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASAL GANGLIA; CATALEPSY; DOPAMINE; STIMULATION; RIGIDITY; AGONISTS;
Keywords:
adenosine A(2A) receptors; striatum; muscle rigidity; electromyogram; mechanomyogram;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Wardas, J Polish Acad Sci, Inst Pharmacol, Dept Neuropsychopharmacol, 12 Smetna St, PL-31343 Krakow, Poland Polish Acad Sci 12 Smetna St Krakow Poland PL-31343 kow, Poland
Citazione:
J. Wardas et al., "The role of striatal adenosine A(2A) receptors in regulation of the muscletone in rats", NEUROSCI L, 276(2), 1999, pp. 79-82

Abstract

The aim of the present study was to assess contribution of striatal adenosine A(2A) receptors to regulation of the muscle tone in rats. The muscle tone was examined by a combined mechano- and electromyographic method, which measured simultaneously muscle resistance (MMG) of a rats hind foot to passive extension and flexion in the ankle joint and the electromyographic activity (EMG) of the antagonistic muscles: gastrocnemius and tibialis anterior. CGS 21680 (1 and 2 mu g/0.5 mu l), injected bilaterally into the rostral part of the striatum, dose-dependently increased both MMG and the EMG. The present results show that stimulation of striatal adenosine A(2A) receptorsby CGS 21680 evokes parkinsonian-like muscle rigidity which may be due to activation of the GABAergic strio-pallidal pathway. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:19:48