Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Day-to-day variability of adequacy indexes in peritoneal dialysis
Autore:
Virga, G; Amici, G; Mastrosimone, S; Biasio, G; Stanic, L; Da Rin, G; Bonadonna, A;
Indirizzi:
Provincial Hosp, Nephrol & Dialysis Unit, Padua, Italy Provincial Hosp Padua Italy Hosp, Nephrol & Dialysis Unit, Padua, Italy Reg Hosp, Div Nephrol & Dialysis, Treviso, Italy Reg Hosp Treviso ItalyReg Hosp, Div Nephrol & Dialysis, Treviso, Italy
Titolo Testata:
NEPHROLOGY DIALYSIS TRANSPLANTATION
fascicolo: 12, volume: 14, anno: 1999,
pagine: 2932 - 2936
SICI:
0931-0509(199912)14:12<2932:DVOAII>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATIONAL COOPERATIVE DIALYSIS; CREATININE CLEARANCE; CAPD; UREA; HEMODIALYSIS; DISCREPANCY; MORBIDITY;
Keywords:
adequacy target; coefficient of variation; creatinine clearance; Kt/V; peritoneal dialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Virga, G Osped P Cosma, Via P Cosma, I-35012 Padua, Italy Osped P Cosma Via P Cosma Padua Italy I-35012 35012 Padua, Italy
Citazione:
G. Virga et al., "Day-to-day variability of adequacy indexes in peritoneal dialysis", NEPH DIAL T, 14(12), 1999, pp. 2932-2936

Abstract

Background. The achievement of dialysis adequacy targets in peritoneal dialysis (PD) is assessed by the calculation of the Kt/V and creatinine clearance (C-Cr) obtained by collecting dialysate and urine, usually two or threetimes a year. Prescription decisions are based on such adequacy assessments, regardless of any variability in the single measurements. The aim of ourstudy was to assess the day-to-day variability of common dialysis adequacyparameters and to evaluate its impact on the adequacy indexes in PD. Methods. Twenty-four patients (14 CAPD, 10 APD) at two centres were studied by means of a triple dialysate and urine collection for a period of 1 week. Variability in the findings for a given patient was expressed by the coefficient of variation (CV%) calculated for peritoneal (p), renal, and total(tot) adequacy parameters. The target Kt/V and C-Cr values were recalculated on the basis of variability. Results. Kt/V was less variable (CV 4.0 and 4.4% for peritoneal Kt/V (pKt/V) and total Kt/V (totKt/V) respectively) than C-Cr (4.7 and 6.0% for peritoneal creatinine clearance (pC(Cr)) and total creatinine clearance (totC(Cr)) respectively) and proved to be a more reliable indicator of adequacy in terms of the CV. Both variability parameters became worse if renal clearance was added to peritoneal clearance. CV in APD proved to be no different from CAPD for all the parameters considered. In our centres dialysis adequacytarget correction for variability provided safe values for weekly Kt/V (pKt/V=1.78-2.10 and totKt/V=1.82-2.15 target 1.7-2.0) and C-Cr/1.73 (pC(Cr)=53.7-64.41 and totC(Cr)=55.1-66.11; target 50-601). Conclusions. Evaluating the adequacy of PD by means of a single measurement should take into account the weekly variability as demonstrated by a triple dialysate and urine collection. Standard adequacy targets can be corrected to allow for variability. Thus one can obtain safe values for prescription decisions based on a single collection result.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 06:49:36