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Titolo:
The presence of ancient human T-cell lymphotropic virus type I provirus DNA in an Andean mummy
Autore:
Li, HC; Fujiyoshi, T; Lou, H; Yashiki, S; Sonoda, S; Cartier, L; Nunez, L; Munoz, I; Horai, S; Tajima, K;
Indirizzi:
Aichi Canc Ctr, Res Inst, Div Epidemiol, Chikusa Ku, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr Nagoya Aichi Japan 4648681 u, Nagoya, Aichi 4648681, Japan Kagoshima Univ, Fac Med, Dept Virol, Kagoshima 8908520, Japan Kagoshima Univ Kagoshima Japan 8908520 t Virol, Kagoshima 8908520, Japan Univ Chile, Dept Clin Neurol, Santiago, Chile Univ Chile Santiago ChileUniv Chile, Dept Clin Neurol, Santiago, Chile N Catholic Univ, Dept Archaeol, San Pedro De Atacama, Region II, Chile N Catholic Univ San Pedro De Atacama Region II Chile a, Region II, Chile Tarapaca Univ, Dept Archaeol, Arica, Region I, Chile Tarapaca Univ Arica Region I Chile Dept Archaeol, Arica, Region I, Chile Grad Univ Adv Studies, Dept Biosyst Sci, Hayamacho 2400193, Japan Grad Univ Adv Studies Hayamacho Japan 2400193 , Hayamacho 2400193, Japan
Titolo Testata:
NATURE MEDICINE
fascicolo: 12, volume: 5, anno: 1999,
pagine: 1428 - 1432
SICI:
1078-8956(199912)5:12<1428:TPOAHT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLETE NUCLEOTIDE-SEQUENCE; LEUKEMIA-VIRUS; ENZYMATIC AMPLIFICATION; GENE; CARRIERS; HTLV-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Tajima, K Aichi Canc Ctr, Res Inst, Div Epidemiol, Chikusa Ku, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr Nagoya Aichi Japan 4648681 Aichi 4648681, Japan
Citazione:
H.C. Li et al., "The presence of ancient human T-cell lymphotropic virus type I provirus DNA in an Andean mummy", NAT MED, 5(12), 1999, pp. 1428-1432

Abstract

The worldwide geographic and ethnic clustering of patients with diseases related to human T-cell lymphotropic virus type I (HTLV-I) may be explained by the natural history of HTLV-I infection(1,2) 2. The genetic characteristics of indigenous people in the Andes are similar to those of the Japanese(3,4), and HTLV-I is generally detected in both groups(5). To clarify the common origin of HTLV-I in Asia and the Andes, we analyzed HTLV-I provirus DNA from Andean mummies about 1,500 years old. Two of 104 mummy bone marrow specimens yielded a band of human beta-globin gene DNA 110 base pairs in length, and one of these two produced bands of HTLV-I-pX (open reading frame encoding p40(x), p27(x)) and HTLV-I-LTR (long terminal repeat) gene DNA 159 base pairs and 157 base pairs in length, respectively. The nucleotide sequences of ancient HTLV-I-pX and HTLV-I-LTR clones isolated from mummy bone marrow were similar to those in contemporary Andeans and Japanese, although there was microheterogeneity in the sequences of some mummy DNA clones. Thisresult provides evidence that HTLV-I was carried with ancient Mongoloids to the Andes before the Colonial era. Analysis of ancient HTLV-I sequences could be a useful tool for studying the history of human retroviral infection as well as human prehistoric migration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 17:23:25