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Titolo:
Genetic evidence of an early exit of Homo sapiens sapiens from Africa through eastern Africa
Autore:
Quintana-Murci, L; Semino, O; Bandelt, HJ; Passarino, G; McElreavey, K; Santachiara-Benerecetti, AS;
Indirizzi:
Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 o Genet & Microbiol, I-27100 Pavia, Italy Univ Hamburg, Math Seminar, D-2000 Hamburg, Germany Univ Hamburg HamburgGermany D-2000 ath Seminar, D-2000 Hamburg, Germany Univ Calabria, Dipartimento Biol Cellulare, Calabria, Italy Univ CalabriaCalabria Italy partimento Biol Cellulare, Calabria, Italy Inst Pasteur, Unite Immunogenet Humaine, Paris, France Inst Pasteur Paris France eur, Unite Immunogenet Humaine, Paris, France
Titolo Testata:
NATURE GENETICS
fascicolo: 4, volume: 23, anno: 1999,
pagine: 437 - 441
SICI:
1061-4036(199912)23:4<437:GEOAEE>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MITOCHONDRIAL-DNA; MTDNA VARIATION; CONTROL REGION; NEW-WORLD; POPULATIONS; ORIGIN; POLYMORPHISMS; DIVERSITY; SEQUENCE; EVOLUTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Santachiara-Benerecetti, AS Univ Pavia, Dipartimento Genet & Microbiol, Via Palestro 3, I-27100 Pavia,Italy Univ Pavia Via Palestro 3 Pavia Italy I-27100
Citazione:
L. Quintana-Murci et al., "Genetic evidence of an early exit of Homo sapiens sapiens from Africa through eastern Africa", NAT GENET, 23(4), 1999, pp. 437-441

Abstract

The out-of-Africa scenario(1) has hitherto provided little evidence for the precise route by which modern humans left Africa. Two major routes of dispersal have been hypothesized: one through North Africa into the Levant, documented by fossil remains(2), and one through Ethiopia along South Asia, for which little, if any, evidence exists(3). Mitochondrial DNA (mtDNA) can be used to trace maternal ancestry, The geographic distribution and variation of mtDNAs can be highly informative in defining potential range expansions and migration routes in the distant past. The mitochondrial haplogroup M, first regarded as an ancient marker of East-Asian origin(4,5), has been found at high frequency in India(6) and Ethiopia(7), raising the question ofits origin. (A haplogroup is a group of haplotypes that share some sequence variations. ) Its variation and geographical distribution suggest that Asian haplogroup M separated from eastern-African haplogroup M more than 50.000 years ago. Two other variants (489C and 10873C) also support a single origin of haplogroup M in Africa. These findings, together with the virtual absence of haplogroup M in the Levant and its high frequency in the South-Arabian peninsula, render Rn the first genetic indicator for the hypothesized exit route from Africa through eastern Africa/western India. This was possibly the only successful early dispersal event of modern humans out of Africa.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 06:53:40