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Titolo:
Mechanisms of egg activation after fertilization
Autore:
De Nadai, C; Chiri, S; Ciapa, B;
Indirizzi:
San Raffaele Sci Inst, DIBIT, I-20132 Milan, Italy San Raffaele Sci Inst Milan Italy I-20132 t, DIBIT, I-20132 Milan, Italy
Titolo Testata:
M S-MEDECINE SCIENCES
fascicolo: 11, volume: 15, anno: 1999,
pagine: 1227 - 1235
SICI:
0767-0974(199911)15:11<1227:MOEAAF>2.0.ZU;2-N
Fonte:
ISI
Lingua:
FRE
Soggetto:
SEA-URCHIN EGGS; CYCLIC ADP-RIBOSE; PHOSPHOLIPASE-C; CA2+ RELEASE; INOSITOL TRISPHOSPHATE; MAMMALIAN EGGS; MOUSE EGGS; SPERM; CALCIUM; OSCILLATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Ciapa, B San Raffaele Sci Inst, DIBIT, 58 Via Olgettina, I-20132 Milan, Italy San Raffaele Sci Inst 58 Via Olgettina Milan Italy I-20132 Italy
Citazione:
C. De Nadai et al., "Mechanisms of egg activation after fertilization", M S-MED SCI, 15(11), 1999, pp. 1227-1235

Abstract

Fertilization results in a series of well-coordinated events, including specific recognition between species, adhesion and fusion between gametes, that finally leads to egg activation. In most deuterostomes, a transient risein intracellular free calcium occurs during egg activation and is necessary for early embryonic development. In the light of recent data obtained in various biological models, from invertebrates to mammals, we discuss how this "calcium signal" is generated from the point of sperm/egg interaction. Different hypotheses have been proposed to explain egg activation. The spermmay bind to a receptor on the egg plasma membrane, linked to G-proteins, tyrosine kinase and PLC gamma, or belonging to the integrins family. Anotherpossibility is that an activating sperm factor enters the egg after fusionestablishes cytoplasmic continuity. Among the putative factors isolated from sperm extracts have been: oscillin, a truncated form of c-kit (a receptor with tyrosine-kinase activity), an unidentified factor associated to the perinuclear material, and a phospholipase C. Finally, in the bomb calcium hypothesis, the sperm would allow the transit of calcium from the external medium into the egg once it has fused with the egg. Results argue for or against each model, which may not be exclusive.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:34:31