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Titolo:
INHIBITION OF MALIGNANT-CELL PROLIFERATION BY CULTURE MEDIA CONDITIONED BY CARDIAC OR SKELETAL-MUSCLE
Autore:
ZINMAN T; SALZBERG S; MALIK Z; SHAINBERG A;
Indirizzi:
BAR ILAN UNIV,OTTO MEYERHOFF DRUG RECEPTOR CTR IL-52900 RAMAT GAN ISRAEL BAR ILAN UNIV,OTTO MEYERHOFF DRUG RECEPTOR CTR IL-52900 RAMAT GAN ISRAEL BAR ILAN UNIV,DEPT LIFE SCI IL-52900 RAMAT GAN ISRAEL
Titolo Testata:
Cell biology international
fascicolo: 3, volume: 21, anno: 1997,
pagine: 133 - 144
SICI:
1065-6995(1997)21:3<133:IOMPBC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTORS; HEART-CELLS; DIFFERENTIATION; PROTEIN; EXPRESSION; BINDING; CANCER; LINE; FIBROBLASTS; LIF;
Keywords:
MUSCLE CULTURES; ANTI TUMOR FACTOR; CONDITIONED MEDIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
T. Zinman et al., "INHIBITION OF MALIGNANT-CELL PROLIFERATION BY CULTURE MEDIA CONDITIONED BY CARDIAC OR SKELETAL-MUSCLE", Cell biology international, 21(3), 1997, pp. 133-144

Abstract

The present work is an attempt to explain the high resistance of muscles to cancer development. We used primary cultures of rat skeletal and cardiac muscle, and examined the effect of the supernatant of these cultures (conditioned medium; CM) on proliferation of cancer cells. The results demonstrated that CM inhibited the proliferation of several types of malignant cells by more than 50%, without a significant inhibition on normal cells. Cell cycle analysis revealed that CM increased the number of cells in S and G2 phases, suggesting a cytostatic effectof CM. For defining the biological properties of the factor(s) which are present in the CM, skeletal muscle cultures were grown in chemically defined medium (serum free medium). The concentrated sample was applied to a Sephadex G-50 column and three fractions were obtained. Onlyone fraction showed inhibitory activity. Four protein bands were observed in this fraction, as revealed by SDS-PAGE. We suggest that some, or all of these proteins are responsible for inhibition of tumor cell replication. (C) 1997 Academic Press Limited.

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Documento generato il 25/09/20 alle ore 06:59:17