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Titolo:
Neonatal lung function in very immature infants with and without RDS
Autore:
Kavvadia, V; Greenough, A; Itakura, Y; Dimitriou, G;
Indirizzi:
Univ London Kings Coll Hosp, Children Nationwide Reg Neonatal Intens Care Ctr, London SE5 9RS, England Univ London Kings Coll Hosp London England SE5 9RS ndon SE5 9RS, England
Titolo Testata:
JOURNAL OF PERINATAL MEDICINE
fascicolo: 5, volume: 27, anno: 1999,
pagine: 382 - 387
SICI:
0300-5577(1999)27:5<382:NLFIVI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYALINE-MEMBRANE DISEASE; BRONCHOPULMONARY DYSPLASIA; EXOGENOUS SURFACTANT; RESPIRATORY-FAILURE; PRETERM INFANTS; PRESSURE; VOLUME; IMPROVEMENT; THERAPY;
Keywords:
respiratory distress syndrome; surfactant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Greenough, A Univ London Kings Coll Hosp, Children Nationwide Reg NeonatalIntens Care Ctr, Denmark Hill, London SE5 9RS, England Univ London Kings Coll Hosp Denmark Hill London England SE5 9RS
Citazione:
V. Kavvadia et al., "Neonatal lung function in very immature infants with and without RDS", J PERIN MED, 27(5), 1999, pp. 382-387

Abstract

Some infants. despite bring born at low gestations(< 28 weeks gestational age) do not develop RDS and are not surfactant treated. The changes in lungfunction during the neonatal period in such infants have nor been explored, hence it is unknown whether they are similar to those of surfactant treated infants with RDS of similar gestational age. Such data would facilitate assessment of the impact of surfactant administration on the lung function abnormalities of very immature infants with RDS. We, therefore, compared the results of neonatal lung function measurements from immature infants withRDS who received surfactant to those from infants with non-RDS respiratorydistress not so treated and matched to the RDS infants for gestational ageand within 10 % of birthweight. Compliance and functional residual capacity (FRC) were measured daily for the first five days and then at 1, 2 and 4 weeks in 16 infants, median gestational age 27 weeks (range 25-27 weeks). Although exogenous surfactant administration to the immature infants with RDS was associated with improvements in lung function, the non RDS, non surfactant treated infants had both higher compliance (p<0.05) and lung volumes (p < 0.01)throughout the perinatal period. These results demonstrate surfactant administration does not fully correct the perinatal lung function abnormalities of very immature infants with RDS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:39:46