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Titolo:
DNA-ploidy analysis correlates with the histogenetic classification of thymic epithelial tumours
Autore:
Gschwendtner, A; Fend, F; Hoffmann, Y; Krugmann, J; Klingler, PJ; Mairinger, T;
Indirizzi:
Innsbruck Univ, Dept Pathol, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 athol, A-6020 Innsbruck, Austria Innsbruck Univ, Dept Surg, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 Surg, A-6020 Innsbruck, Austria
Titolo Testata:
JOURNAL OF PATHOLOGY
fascicolo: 4, volume: 189, anno: 1999,
pagine: 576 - 580
SICI:
0022-3417(199912)189:4<576:DACWTH>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMOMA; TUMORS; SUBCLASSIFICATION; CARCINOMA; MALIGNANCY; SYSTEM; CELLS; P53;
Keywords:
thymomas; neoplasm; classification; DNA cytometry; ploidy analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Gschwendtner, A Innsbruck Univ, Dept Pathol, Muellerstr 44, A-6020 Innsbruck, Austria Innsbruck Univ Muellerstr 44 Innsbruck Austria A-6020 ria
Citazione:
A. Gschwendtner et al., "DNA-ploidy analysis correlates with the histogenetic classification of thymic epithelial tumours", J PATHOLOGY, 189(4), 1999, pp. 576-580

Abstract

The ploidy values of the epithelial component were determined in a series of thymomas and organotypic thymic carcinomas using image cytometry and theresults mere compared with the histological tumour subtypes according to the histogenetic classification introduced by Marine, Muller Hermelink, and Kirchner (MMHK). Forty-six cases of thymic epithelial tumours were includedin the study. After reclassification according to the MMHK classification,the distribution among the subtypes was as follows: three medullary, nine mixed type, five predominantly cortical (organoid), 16 cortical thymomas, and 13 well-differentiated thymic carcinomas. Single cell preparations were made from paraffin-embedded tumour tissue and stained according to Feulgen. Ploidy analysis was performed using an automated image analysis system. Infive cases, DNA cytometry could not be performed, for technical reasons. The remaining 41 cases consisted of 11 diploid and 30 non-diploid tumours. The percentage of aneuploid rumours in the different subtypes increased frommedullary (0 per cent) through mixed type (44.4 per cent), predominantly cortical (75 per cent), cortical (83.3 per cent) to well-differentiated thymic carcinomas (100 per cent). DNA-ploidy determination using image cytometry correlates with the concept of the MMHK classification of thymomas. Copyright (C) 1999 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:03:37