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Titolo:
Expression of Fas and Fas ligand in cutaneous B-cell lymphomas
Autore:
Zoi-Toli, O; Meijer, CJLM; Oudejans, JJ; De Vries, E; Van Beek, P; Willemze, R;
Indirizzi:
Free Univ Amsterdam Hosp, Dept Dermatol, NL-1081 HV Amsterdam, NetherlandsFree Univ Amsterdam Hosp Amsterdam Netherlands NL-1081 HV m, Netherlands Free Univ Amsterdam Hosp, Dept Pathol, Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands , Amsterdam, Netherlands
Titolo Testata:
JOURNAL OF PATHOLOGY
fascicolo: 4, volume: 189, anno: 1999,
pagine: 533 - 538
SICI:
0022-3417(199912)189:4<533:EOFAFL>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-HODGKINS-LYMPHOMAS; FACTOR RECEPTOR SUPERFAMILY; BCL-2 PROTEIN EXPRESSION; DIFFERENTIAL EXPRESSION; PERIPHERAL-BLOOD; FOLLICLE CENTER; MOLECULAR-CLONING; SURFACE ANTIGEN; MESSENGER-RNA; T-LYMPHOCYTE;
Keywords:
cutaneous B-cell lymphoma; Fas; Fasl; apoptosis; bcl-2; ICAM-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Willemze, R Free Univ Amsterdam Hosp, Dept Dermatol, Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands Free Univ Amsterdam Hosp Boelelaan 1117 Amsterdam Netherlands NL-1081 HV
Citazione:
O. Zoi-Toli et al., "Expression of Fas and Fas ligand in cutaneous B-cell lymphomas", J PATHOLOGY, 189(4), 1999, pp. 533-538

Abstract

Primary cutaneous B-cell lymphomas (CBCLs) represent a rare, but distinct group of B-cell neoplasms with a different clinical behaviour to B-cell lymphomas secondarily involving the skin. Fas-Fas ligand (Fasl) expression wasinvestigated in a group of primary and secondary CBCLs to gain an insight into the putative role of these apoptotic molecules in the clinical behaviour of these lymphomas, Frozen and paraffin sections from 32 patients with aCBCL were investigated for Fas and Fasl expression, using immunohistochemistry. This group included 24 primary CBCLs [14 primary cutaneous follicle centre cell lymphomas (PCFCCLs), six primary cutaneous large B-cell lymphomas (PCLBCLs) on the leg, and four primary cutaneous immunocytomas] and eightsecondary CBCLs, The results were correlated with follow-up data, bcl-2, and ICAM-1 expression. High Fas expression and absent or low Fasl expressionwere detected in the vast majority of PCFCCLs and immunocytomas. The groupof PCLBCLs on the leg, which have an intermediate prognosis, showed variable results with relatively higher Fasl expression. The highest Fasl expression was found in the more aggressive secondary CBCLs whereas in this group,Fas was undetectable in five of eight cases. Statistical analysis showed that Fas and ICAM-1 expression was strongly related to a favourable prognosis, whereas expression of Fasl and bcl-2 was related to a very poor prognosis. Although only type of CBCL and-age, but not Fas, Fasl, bcl-2, and ICAM-1expression, proved independent prognostic parameters using multivariate analysis, the results of this study suggest that differences in the expression of Fas and Fasl, as well as bcl-2 and ICAM-1, contribute to the differences in clinical behaviour between these different types of CBCL, Copyright (C) 1999 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 09:27:34