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Titolo:
Evaluation of a new troponin I method on the Bayer Immuno 1 (TM) immunoassay analyser
Autore:
Clark, GH; Kennon, SRO; Price, CP;
Indirizzi:
Barts & London NHS Trust, Dept Clin Biochem, London, England Barts & London NHS Trust London England t Clin Biochem, London, England Barts & London NHS Trust, Dept Cardiol, London, England Barts & London NHSTrust London England , Dept Cardiol, London, England St Bartholomews & Royal London Sch Med & Dent, Dept Clin Biochem, London, England St Bartholomews & Royal London Sch Med & Dent London England n, England
Titolo Testata:
JOURNAL OF IMMUNOASSAY
fascicolo: 4, volume: 20, anno: 1999,
pagine: 253 - 273
SICI:
0197-1522(1999)20:4<253:EOANTI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; ACUTE CORONARY SYNDROMES; CHRONIC-RENAL-FAILURE; CREATINE-KINASE-MB; CARDIAC TROPONIN; RISK STRATIFICATION; UNSTABLE ANGINA; DIAGNOSIS; SERUM; PHOSPHORYLATION;
Keywords:
troponins; immunoassay; myocardial infarction; clinical cut off values;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Clark, GH Barts & London NHS Trust, Dept Clin Biochem, London, England Barts & London NHS Trust London England chem, London, England
Citazione:
G.H. Clark et al., "Evaluation of a new troponin I method on the Bayer Immuno 1 (TM) immunoassay analyser", J IMMUNOASS, 20(4), 1999, pp. 253-273

Abstract

We have evaluated the analytical and clinical performance of an automated immunoassay for serum cardiac troponin I (Bayer Immune 1(TM), Bayer Diagnostics, Tarrytown, NY). The between batch imprecision was found to be between1.2 and 3.2% over the concentration range 2.5 - 34.0 mu g/L. The analytical range obtained from duplicate analysis of patient samples and defined as a coefficient of variation of 10% or less was 0.3 - 200 mu g/L. The detection limit was found to be less than 0.1 mu g/L. A method comparison with theDade Stratus method (Dade Behring, Wilmington, DE) yielded regression statistics with a slope of 0.705 and an intercept of -0.260. An analysis of samples from 40 patients with renal failure demonstrated six with detectable levels of troponin 1 (0.2 - 1.9 mu g/L). Samples from patients with paraproteinaemia did not demonstrate detectable troponin I (from n = 30); however, two patients with elevated rheumatoid factor titers (from n = 20) demonstrated a detectable amount of troponin I (0.1 and 0.2 mu g/L). In a study of 100 patients admitted with acute chest pain and a diagnosis of unstable angina, 6 were subsequently diagnosed as having suffered a myocardial infarction. On admission the sensitivity and specificity of the troponin I results were 26.7% and 94.7%, respectively, moving to 100% and 83% 12 hours after admission.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 14:23:20