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Titolo:
Diffuse bipolar cells provide input to OFF parasol ganglion cells in the macaque retina
Autore:
Jacoby, RA; Wiechmann, AF; Amara, SG; Leighton, BH; Marshak, DW;
Indirizzi:
Univ Texas, Sch Med, Dept Neurobiol & Anat, Houston, TX 77225 USA Univ Texas Houston TX USA 77225 t Neurobiol & Anat, Houston, TX 77225 USA Univ Oklahoma, Hlth Sci Ctr, Dept Cell Biol, Oklahoma City, OK 73190 USA Univ Oklahoma Oklahoma City OK USA 73190 iol, Oklahoma City, OK 73190 USA Univ Oklahoma, Hlth Sci Ctr, Dept Ophthalmol, Oklahoma City, OK 73190 USA Univ Oklahoma Oklahoma City OK USA 73190 mol, Oklahoma City, OK 73190 USA Oregon Hlth Sci Univ, Vollum Inst, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 m Inst, Portland, OR 97201 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 1, volume: 416, anno: 2000,
pagine: 6 - 18
SICI:
0021-9967(20000103)416:1<6:DBCPIT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMATE TRANSPORTER SUBTYPES; MARMOSET CALLITHRIX-JACCHUS; CAT RETINA; PRIMATE RETINA; MONKEY RETINA; DIFFERENTIAL EXPRESSION; ELECTRON-MICROSCOPY; SPATIAL DENSITY; RABBIT RETINA; WORLD MONKEY;
Keywords:
confocal microscopy; electron microscopy; calbindin; primate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Marshak, DW Univ Texas, Sch Med, Dept Neurobiol & Anat, POB 20708, Houston, TX 77225 USA Univ Texas POB 20708 Houston TX USA 77225 ouston, TX 77225 USA
Citazione:
R.A. Jacoby et al., "Diffuse bipolar cells provide input to OFF parasol ganglion cells in the macaque retina", J COMP NEUR, 416(1), 2000, pp. 6-18

Abstract

Parasol retinal ganglion cells are more sensitive to luminance contrast and respond more transiently at all levels of adaptation than midget ganglioncells. This may be due, in part, to differences between bipolar cells thatprovide their input, and the goal of these experiments was to study these differences. Midget bipolar cells are known to be presynaptic to midget ganglion cells. To identify the bipolar cells presynaptic to parasol cells, these ganglion cells were intracellularly injected with Neurobiotin, cone bipolar cells were immunolabeled, and the double-labeled material was analyzed. In the electron microscope, we found that DB3 diffuse bipolar cells labeled by using antiserum to calbindin D-28k were presynaptic to OFF parasol cells. In the confocal microscope, DB3 bipolars costratified with OFF parasolcell dendrites and made significantly more appositions with them than expected due to chance. Flat midget bipolar cells were labeled with antiserum to recoverin. Although they made a few appositions with parasol cells, the number was no greater than would be expected when two sets of processes haveoverlapping distributions in the inner plexiform layer. DB2 diffuse bipolar cells were labeled with antibodies to excitatory amino acid transporter 2, and they also made appositions with OFF parasol cells. These results suggest that DB2 bipolar cells are also presynaptic to OFF parasol ganglion cells, but midget bipolar cells are not. We estimate that midperipheral OFF parasol cells receive approximate to 500 synapses from 50 DB3 bipolar cells that, in turn, receive input from 250 cones. J. Comp. Neurol. 416:6-18, 2000. (C) 2000 Wiley-Liss, Inc.

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Documento generato il 04/04/20 alle ore 21:46:16