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Titolo:
Plasticity of the auditory brainstem: Cochleotomy-induced changes of calbindin-D28k expression in the rat
Autore:
Forster, CR; Illing, RB;
Indirizzi:
Univ Freiburg, HNO Klin, Dept Otorhinolaryngol, Neurobiol Res Lab, D-79106Freiburg, Germany Univ Freiburg Freiburg Germany D-79106 Res Lab, D-79106Freiburg, Germany
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 2, volume: 416, anno: 2000,
pagine: 173 - 187
SICI:
0021-9967(20000110)416:2<173:POTABC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM-BINDING PROTEINS; GROWTH-ASSOCIATED PROTEIN; SUPERIOR OLIVARY COMPLEX; COCHLEAR NUCLEUS; MESSENGER-RNA; REACTIVE ASTROCYTES; INFERIOR COLLICULUS; NEURONS; IMMUNOREACTIVITY; STEM;
Keywords:
auditory system; superior olive; cochlear nucleus; inferior colliculus; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Illing, RB Univ Freiburg, HNO Klin, Dept Otorhinolaryngol, Neurobiol Res Lab, Killianst 5, D-79106 Freiburg, Germany Univ Freiburg Killianst 5 Freiburg Germany D-79106 rg, Germany
Citazione:
C.R. Forster e R.B. Illing, "Plasticity of the auditory brainstem: Cochleotomy-induced changes of calbindin-D28k expression in the rat", J COMP NEUR, 416(2), 2000, pp. 173-187

Abstract

Calbindin is a calcium binding protein that is characteristically expressed in several auditory brainstem nuclei during ontogeny and is thought to serve as a buffer, protecting cells against toxic levels of calcium. Upon maturation, calbindin is drastically reduced or entirely lost in many auditorynuclei. We made cochleotomies in mature rats to study effects of deafeningand deafferentation on the expression of calbindin in the auditory brainstem. Following unilateral cochleotomy, we observed a substantial increase inthe number of calbindin-immunoreactive fibers and boutons in the ventral subdivisions of the ipsilateral cochlear nucleus. At the same time, calbindin-positive astrocytes emerged in the dorsal and ventral cochlear nucleus. Beyond the immediately affected ipsilateral cochlear nucleus, we found calbindin-positive neurons in the lateral superior olive and in the central inferior colliculus, both contralateral to the operation. The loss of one cochlea reduces auditory input and puts the flow of neuronal activity originating in the two ears out of balance. Our findings indicate that the need for the neuronal networks in the auditory brainstem to adjust to this drastically changed pattern of sensory signals invokes the expression of calbindin inglial cells as well as in directly and indirectly affected neuronal cell populations. J. Comp. Neurol. 416:173-187, 2000. (C) 2000 Wiley-Liss, Inc.

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Documento generato il 07/07/20 alle ore 13:46:42