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Titolo:
Topology, subcellular localization, and sequence diversity of the Mlo family in plants
Autore:
Devoto, A; Piffanelli, P; Nilsson, I; Wallin, E; Panstruga, R; von Heijne, G; Schulze-Lefert, P;
Indirizzi:
John Innes Ctr Plant Sci Res, Sainsbury Lab, Norwich NR4 7UH, Norfolk, England John Innes Ctr Plant Sci Res Norwich Norfolk England NR4 7UH olk, England Univ Stockholm, Dept Biochem, S-10691 Stockholm, Sweden Univ Stockholm Stockholm Sweden S-10691 ochem, S-10691 Stockholm, Sweden
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 49, volume: 274, anno: 1999,
pagine: 34993 - 35004
SICI:
0021-9258(199912)274:49<34993:TSLASD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-COUPLED RECEPTORS; MEMBRANE-PROTEINS; ENDOPLASMIC-RETICULUM; ARABIDOPSIS-THALIANA; LEADER PEPTIDASE; POWDERY MILDEW; SIGNAL PEPTIDE; RESISTANCE; GENE; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Schulze-Lefert, P John Innes Ctr Plant Sci Res, Sainsbury Lab, Colney Lane, Norwich NR4 7UH,Norfolk, England John Innes Ctr Plant Sci Res Colney LaneNorwich Norfolk England NR4 7UH
Citazione:
A. Devoto et al., "Topology, subcellular localization, and sequence diversity of the Mlo family in plants", J BIOL CHEM, 274(49), 1999, pp. 34993-35004

Abstract

Barley Mlo defines the founder of a novel class of plant integral membraneproteins. Lack of the wild type protein leads to broad spectrum disease resistance against the pathogenic powdery mildew fungus and deregulated leaf cell death. Scanning N-glycosylation mutagenesis and Mlo-Lep fusion proteins demonstrated that Mlo is membrane-anchored by 7 transmembrane (TM) helices such that the N terminus is located extracellularly and the C terminus intracellularly. Fractionation of leaf cells and immunoblotting localized theprotein to the plant plasma membrane. A genome-wide search for Mlo sequence-related genes in Arabidopsis thaliana revealed approximately 35 family members, the only abundant gene family encoding 7 TM proteins in higher plants. The sequence variability of Mlo family members within a single species, their topology and subcellular localization are reminiscent of the most abundant class of metazoan 7 TM receptors, the G-protein-coupled receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/10/20 alle ore 06:37:24