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Titolo:
IONOTROPIC GLUTAMATE RECEPTORS AND NITRIC-OXIDE SYNTHESIS IN THE RAT STRIATUM
Autore:
EAST SJ; PARRYJONES A; BROTCHIE JM;
Indirizzi:
UNIV MANCHESTER,SCH BIOL SCI,DIV NEUROSCI,ROOM 1-124,OXFORD RD MANCHESTER M13 9PT LANCS ENGLAND
Titolo Testata:
NeuroReport
fascicolo: 1, volume: 8, anno: 1996,
pagine: 71 - 75
SICI:
0959-4965(1996)8:1<71:IGRANS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIC-GMP FORMATION; NADPH-DIAPHORASE; H-3 DOPAMINE; NEURONS; ACTIVATION; ARGININE; PATHWAY; RELEASE; SLICES; HIPPOCAMPUS;
Keywords:
ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONATE (AMPA) RECEPTORS CYCLIC GMP; INTERNEURONS; KAINATE RECEPTORS; (2S,4R)-4-METHYLGLUTAMATE; NITRIC OXIDE; N-METHYL-D-ASPARTATE RECEPTORS; STRIATUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
S.J. East et al., "IONOTROPIC GLUTAMATE RECEPTORS AND NITRIC-OXIDE SYNTHESIS IN THE RAT STRIATUM", NeuroReport, 8(1), 1996, pp. 71-75

Abstract

A population of interneurones in the rat striatum contain neuronal nitric oxide synthase (nNOS). The nitric oxide (NO)-cGMP pathway may modulate neurotransmission in this brain area but little is known about the physiological stimulator(s) of nNOS in striatal neurones. Exposure of intact striatal slices to N-methyl-D-aspartate (NMDA) (100 mu M, 8 min) caused an almost two-fold increase in cGMP levels (EC50 similar to 25 mu M), which was inhibited by the nNOS inhibitor N-omega-L-nitroarginine (IC50 similar to 70 nM) and by removing external Ca2+. Neither(S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) nor the kainate receptor agonist (2S,4R)-4-methylglutamate increased basalcGMP levels. Thus, glutamatergic striatal inputs could stimulate a NO-cGMP pathway in the striatum via NMDA receptors but not via AMPA or kainate receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:40:57