Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Assessment of limb muscle and adipose tissue by dual-energy X-ray absorptiometry using magnetic resonance imaging for comparison
Autore:
Fuller, NJ; Hardingham, CR; Graves, M; Screaton, N; Dixon, AK; Ward, LC; Elia, M;
Indirizzi:
MRC, Dunn Clin Nutr Ctr, Cambridge CB2 2DH, England MRC Cambridge England CB2 2DH Clin Nutr Ctr, Cambridge CB2 2DH, England Addenbrookes Hosp, Dept Radiol, Cambridge CB2 2QQ, England Addenbrookes Hosp Cambridge England CB2 2QQ , Cambridge CB2 2QQ, England Univ Cambridge, Cambridge, England Univ Cambridge Cambridge EnglandUniv Cambridge, Cambridge, England Univ Queensland, Dept Biochem, Brisbane, Qld 4072, Australia Univ Queensland Brisbane Qld Australia 4072 Brisbane, Qld 4072, Australia
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 12, volume: 23, anno: 1999,
pagine: 1295 - 1302
SICI:
0307-0565(199912)23:12<1295:AOLMAA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE; URINARY CREATININE; COMPUTERIZED-TOMOGRAPHY; MASS; DENSITY;
Keywords:
muscle; adipose tissue; MRI; DXA; creatinine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Fuller, NJ MRC, Dunn Clin Nutr Ctr, Hills Rd, Cambridge CB2 2DH, England MRC Hills Rd Cambridge England CB2 2DH bridge CB2 2DH, England
Citazione:
N.J. Fuller et al., "Assessment of limb muscle and adipose tissue by dual-energy X-ray absorptiometry using magnetic resonance imaging for comparison", INT J OBES, 23(12), 1999, pp. 1295-1302

Abstract

OBJECTIVE: To use magnetic resonance imaging (MRI) to validate estimates of muscle and adipose tissue (AT) in lower limb sections obtained by dual-energy X-ray absorptiometry (DXA) modelling. DESIGN: MRI measurements were used as reference for validating limb muscleand AT estimates obtained by DXA models that assume fat-free soft tissue (FFST) comprised mainly muscle: model A accounted for bone hydration only; model B also applied constants for FFST in bone and skin and fat in muscle and AT; model C was as model B but allowing for variable fat in muscle and AT. SUBJECTS: Healthy men (n = 8) and women (n = 8), ages 41 - 62 y; mean (s.d.) body mass indices (BMIs) of 28.6 (5.4) kg/m(2) and 25.1 (5.4) kg/m2, respectively. MEASUREMENTS: MRI scans of the legs and whole body DXA scans were analysedfor muscle and AT content of thigh (20 cm) and lower leg (10 cm) sections;24 h creatinine excretion was measured. RESULTS: Model A overestimated thigh muscle volume (MRI mean, 2.3 l) substantially (bias 0.36 l), whereas model B underestimated it by only 2% (bias 0.045 l). Lower leg muscle (MRI mean, 0.6 l) was better predicted using model A (bias 0.04 l, 7% overestimate) than model B (bias 0.1 l, 17% underestimate). The 95% limits of agreement were high for these models (thigh,+/- 20%; lower leg,+/- 47%). Model C predictions were more discrepant than those of model B. There was generally less agreement between MRI and all DXA models for AT. Measurement variability was generally less for DXA measurements of FFST (coefficient of variation 0.7 - 1.8%) and fat (0.8 - 3.3%) than model B estimates of muscle (0.5-2.6%) and AT (3.3 - 6.8%), respectively. Despite strong relationships between them, muscle mass was overestimated by creatinine excretion with highly variable predictability. CONCLUSION: This study has shown the value of DXA models for assessment ofmuscle and AT in leg sections, but suggests the need to re-evaluate some of the assumptions upon which they are based.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 18:24:38