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Titolo:
Host immunosurveillance contributes to the control of erbB-2 overexpression in HLA-A2-breast-cancer patients
Autore:
Nistico, P; Mottolese, M; Cascioli, S; Benevolo, M; Del Bello, D; Di Modugno, F; Rubiu, O; Gentile, FP; Botti, C; Venturo, I; Natali, PG;
Indirizzi:
CRS, Regina Elena Canc Inst, Immunol Lab, Rome, Italy CRS Rome ItalyCRS, Regina Elena Canc Inst, Immunol Lab, Rome, Italy Regina Elena Canc Inst, Dept Pathol, Rome, Italy Regina Elena Canc Inst Rome Italy a Canc Inst, Dept Pathol, Rome, Italy CRS, Regina Elena Canc Inst, Lab Med Phys, Rome, Italy CRS Rome ItalyCRS, Regina Elena Canc Inst, Lab Med Phys, Rome, Italy Regina Elena Canc Inst, Dept Surg 1, Rome, Italy Regina Elena Canc Inst Rome Italy a Canc Inst, Dept Surg 1, Rome, Italy Regina Elena Canc Inst, Dept Med Oncol, Rome, Italy Regina Elena Canc Inst Rome Italy anc Inst, Dept Med Oncol, Rome, Italy
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 6, volume: 84, anno: 1999,
pagine: 598 - 603
SICI:
0020-7136(199912)84:6<598:HICTTC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-I PHENOTYPES; T-CELL CLONES; BREAST-CANCER; MONOCLONAL ANTIBODIES; MELANOMA-CELLS; HLA; ANTIGENS; CARCINOMAS; TRANSPORTER; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Nistico, P CRS, Ist Tumori Regina Elena, Lab Pathophysiol, Via Messi Oro 156, I-00158Rome, Italy CRS Via Messi Oro 156 Rome Italy I-00158 6, I-00158Rome, Italy
Citazione:
P. Nistico et al., "Host immunosurveillance contributes to the control of erbB-2 overexpression in HLA-A2-breast-cancer patients", INT J CANC, 84(6), 1999, pp. 598-603

Abstract

Overexpression of gp185(erbB-2) has been associated with reduced survival in breast-cancer patients. Our earlier results, now confirmed in a larger cohort of patients (798), evidenced that the HLA-A2 allele may participate in the modulation of the erbB-2 tumor phenotype in vivo, In the present study, we evaluated other clinico-biopathologic parameters possibly involved inthe host immune response against erbB-2, Localization of the CD3(+) T-cellinfiltrate was taken into consideration in 705 primary breast tumors, and expression of HLA-class-I and HLA-A2 antigens was evaluated in a subgroup of 170 frozen primary tumors of HLA-A2-positive patients, The presence or the absence of HLA-class-I and HLA-A2 antigens in primary tumors did not correlate with erbB-2 expression. However, HLA-A2-positive tumors preferentially showed intratumoral lymphocyte localization, whereas the lesions displaying undetectable HLA-class-I expression showed peritumoral CD3(+) T-cell localization. Taking into account erbB-2 immunoreactivity, we found that the relationship between HLA-A2 expression and intratumoral CD3(+) T-lymphocyte localization is significant only in the erbB-2 negative subset, whereas therelationship between lack of HLA-class-I expression and peritumoral CD3(+)T-lymphocyte localization is significant only in the erbB-2-positive subset, These data provide novel in vivo evidence of the possible contribution of the host immune system to control of erbB-2 oncogene overexpression in breast cancer. Int. J. Cancer (Pred. Oncol.) 84:598-603, 1999. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 00:41:44