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Titolo:
Evaluation of multiple bio-pathological factors in colorectal adenocarcinomas: Independent prognostic role of p53 and Bcl-2
Autore:
Buglioni, S; DAgnano, I; Cosimelli, M; Vasselli, S; DAngelo, C; Tedesco, M; Zupi, G; Mottolese, M;
Indirizzi:
Regina Elena Canc Inst, Dept Pathol, I-00161 Rome, Italy Regina Elena CancInst Rome Italy I-00161 pt Pathol, I-00161 Rome, Italy Regina Elena Canc Inst, Expt Chemotherapy Lab, Rome, Italy Regina Elena Canc Inst Rome Italy t, Expt Chemotherapy Lab, Rome, Italy Regina Elena Canc Inst, Dept Surg 2, Rome, Italy Regina Elena Canc Inst Rome Italy a Canc Inst, Dept Surg 2, Rome, Italy
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 6, volume: 84, anno: 1999,
pagine: 545 - 552
SICI:
0020-7136(199912)84:6<545:EOMBFI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-PLOIDY; EXPRESSION; CARCINOMA; PROTEIN; PROLIFERATION; SURVIVAL; CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Mottolese, M Regina Elena Canc Inst, Dept Pathol, Viale Regina Elena 291, I-00161 Rome,Italy Regina Elena Canc Inst Viale Regina Elena 291 Rome Italy I-00161
Citazione:
S. Buglioni et al., "Evaluation of multiple bio-pathological factors in colorectal adenocarcinomas: Independent prognostic role of p53 and Bcl-2", INT J CANC, 84(6), 1999, pp. 545-552

Abstract

About 40% of patients with colorectal carcinoma will develop local or distant tumour recurrences. Integrated analyses of bio-pathological markers, predictive of tumour aggressiveness, may offer a more rational approach to planning adjuvant therapy. To this end, we analysed the correlation between p53 accumulation, Bcl-2 expression, DNA ploidy, cell proliferation and conventional clinico-pathological parameters by testing the prognostic significance of these variables in a series of 171 colorectal carcinoma patients with longterm follow-up. The relationships among the various bio-pathological parameters, analysed by multiple correspondence analysis, showed 2 different clinico-biological profiles. The first, characterised by p53 negativity, Bcl-2 positivity, diploidy, low percentage of cells in S-phase (%S-phase), a low Ki-67 score, is associated with Dukes' A-B stage, well differentiatedtumours and lack of relapse. The second, defined by p53 positivity, Bcl-2 negativity, aneuploidy, high %S-phase and elevated Ki-67 score, correlates with Dukes' C-D stage, poorly differentiated tumours and presence of relapse. When these parameters were examined according to Kaplan-Meier's method, significantly shorter disease-free (DFS) and overall survival (OS) were also observed in patients bearing p53 positive and Bcl-2 negative tumours, in Dukes' B stage. In multivariate analysis, p53 accumulation and Bcl-2 expression emerged as independent predictors of a worse and better clinical outcome, respectively. Our results indicate that, in colorectal adenocarcinomas,a biological profile, based on the combined evaluation of p53 and Bcl-2, may be useful for identifying high risk patients to be enrolled in an adjuvant setting, mainly in an early stage of the disease. Int. J. Cancer (Pred. Oncol.) 84:545-552, 1999. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:20:12