Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The role of endothelin-1 in pressure autoregulation of cerebral blood flowin rats
Autore:
Mascia, L; Piper, IR; Andrews, PJD; Souter, MJ; Webb, DJ;
Indirizzi:
Univ Bari, Osped Policlin, Ist Anestesiol & Rianimazione, I-70122 Bari, Italy Univ Bari Bari Italy I-70122 stesiol & Rianimazione, I-70122 Bari, Italy Inst Neurol Sci, Dept Clin Phys, Glasgow, Lanark, Scotland Inst Neurol Sci Glasgow Lanark Scotland Phys, Glasgow, Lanark, Scotland Univ Edinburgh, Western Gen Hosp, Dept Anaesthet, Edinburgh EH4 2XU, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH4 2XU Midlothian, Scotland Univ Edinburgh, Western Gen Hosp, Dept Med, Edinburgh EH4 2XU, Midlothian,Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH4 2XU Midlothian,Scotland
Titolo Testata:
INTENSIVE CARE MEDICINE
fascicolo: 11, volume: 25, anno: 1999,
pagine: 1282 - 1286
SICI:
0342-4642(199911)25:11<1282:TROEIP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTRACTILE RESPONSES; RESISTANCE ARTERIOLES; RECEPTOR ANTAGONIST; CIRCULATION; VASOSPASM; VASOCONSTRICTION; RELAXATION; BOSENTAN; ISCHEMIA; CLONING;
Keywords:
cerebral perfusion pressure; intracranial pressure; mean arterial pressure; endothelium; pressure autoregulation; cerebral blood flow;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Mascia, L Univ Bari, Osped Policlin, Ist Anestesiol & Rianimazione, PiazzaG Cesare 11, I-70122 Bari, Italy Univ Bari Piazza G Cesare 11 Bari Italy I-70122 122 Bari, Italy
Citazione:
L. Mascia et al., "The role of endothelin-1 in pressure autoregulation of cerebral blood flowin rats", INTEN CAR M, 25(11), 1999, pp. 1282-1286

Abstract

Objective:To investigate the role of the endothelin system in pressure autoregulation of cerebral blood flow (CBF) in rats. Design: We tested pressure autoregulation by increasing cerebral perfusionpressure (CPP; mean arterial pressure-intracranial pressure) with norepinephrine(0.08 mu g.kg(-1).min(-1) for 30 min) twice in ten anesthetized normocapnic rats. The first test was performed without (control test) and the second test after administration of the combined endothelin ETA/B receptor antagonist, bosentan, i.v. (30 mg/kg; drug test). CBF was measured by the hydrogen clearance technique. Results: During the control test, norepinephrine infusion increased CPP by21 +/- 2 (23 +/- 2%) mmHg (mean I SEM; p < 0.001) and CBF by 3.6 +/- 3.1 (6 +/- 8%) ml/100 g/min (p = 0.5, Fig. 1); during the drug lest, norepinephrine infusion increased CPP by 18 +/- 1 (20 +/- 2%) mmHg (p < 0.001) and CBFby 15.8 +/- 4.1 (46 +/- 13%) ml/100 g/min (p = 0.004), Mean arterial pressure was not affected by bosentan infusion (p = 0.2), PaCO2 levels were stable during the tests (40.2 +/- 1.4 mmHg),Conclusions: The endothelin system is involved in cerebral pressure autoregulation in a rodent model in vivo. The role of this system under pathophysiologic conditions such as subarachnoid hemorrhage, where basal vascular tone and its regulation may be altered, remains to be defined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:34:29