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Titolo:
Improvement of murine immune functions in vitro by thioproline
Autore:
Correa, R; Del Rio, M; De la Fuente, M;
Indirizzi:
Univ Complutense, Fac Biol Sci, Dept Anim Physiol, E-28040 Madrid, Spain Univ Complutense Madrid Spain E-28040 nim Physiol, E-28040 Madrid, Spain
Titolo Testata:
IMMUNOPHARMACOLOGY
fascicolo: 3, volume: 44, anno: 1999,
pagine: 281 - 291
SICI:
0162-3109(199911)44:3<281:IOMIFI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT CELLULAR CYTOTOXICITY; NF-KAPPA-B; ANTIOXIDANT THIOPROLINE; ADHESION MOLECULE-1; MACROPHAGE FUNCTION; BETA-CAROTENE; ASCORBIC-ACID; VITAMIN-E; IN-VITRO; CELLS;
Keywords:
thioproline; thiols; macrophage; lymphocyte; natural cytotoxicity; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: De la Fuente, M Univ Complutense, Fac Biol Sci, Dept Anim Physiol, E-28040Madrid, Spain Univ Complutense Madrid Spain E-28040 8040 Madrid, Spain
Citazione:
R. Correa et al., "Improvement of murine immune functions in vitro by thioproline", IMMUNOPHARM, 44(3), 1999, pp. 281-291

Abstract

Previous studies have shown that several immune functions were improved inmice after the ingestion of a thioproline (thiazolidine-4-carboxilic acid)enriched diet. In the present work, we have studied the in vitro effects of several concentrations of this thiol compound (0.1, 0.5, 1, 2.5 and 5 mM)on the most relevant functions of three pivotal immune cells, namely, macrophages, lymphocytes, and natural killer (NK) cells from BALB/c mice. The results show that thioproline stimulates the phagocytic process of macrophages, increasing the mobility directed to the inflammatory focus (chemotaxis)and the phagocytosis of inert particles. It increases the adherence and the chemotaxis capacities of lymphocytes, their proliferative activity and favours the natural cytotoxic activity that could improve the capacity to destroy malignant cells. Thioproline concentrations of 0.5 and 1 mM were the most effective regarding the different functions analysed. These results suggest that the improvement of immune functions, observed in previous work, after thioproline-enriched diet ingestion is due to a direct action of this thiol compound on immune cells. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 13/07/20 alle ore 11:08:59