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Titolo:
Immune response following fresh arterial homograft replacement for aortoiliac graft infection
Autore:
Mirelli, M; Stella, A; Faggioli, GL; Scolari, MP; Iannelli, S; Freyrie, A; Buscaroli, A; De Santis, L; Resta, F; Bonomini, V; DAddato, M;
Indirizzi:
S Orsola M Malpighi Hosp, Dept Vasc Surg, Bologna, Italy S Orsola M Malpighi Hosp Bologna Italy , Dept Vasc Surg, Bologna, Italy
Titolo Testata:
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
fascicolo: 5, volume: 18, anno: 1999,
pagine: 424 - 429
SICI:
1078-5884(199911)18:5<424:IRFFAH>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICAL RENAL-TRANSPLANTATION; LINKED-IMMUNOSORBENT-ASSAY; PRIMERS PCR-SSP; FLOW-CYTOMETRY; ALLOGRAFT REPLACEMENT; ANTIGENS; AMPLIFICATION; ANTIBODIES; REJECTION; WORKSHOP;
Keywords:
arterial; homograft; immunologic; graft; infection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Mirelli, M Serv Chirurg Vasc, Via Massarenti 9, I-40138 Bologna, Italy Serv Chirurg Vasc Via Massarenti 9 Bologna Italy I-40138 Italy
Citazione:
M. Mirelli et al., "Immune response following fresh arterial homograft replacement for aortoiliac graft infection", EUR J VAS E, 18(5), 1999, pp. 424-429

Abstract

Introduction: this prospective study defines the immune response to fresh arterial homograft replacement for graft infection. Materials and methods: ten patients who underwent ABO-compatible homografttransplantation were studied for anti-HLA antibody production, and CD3-CD4-CD8-positive lymphocytes subset. Immunological studies were performed preoperatively, and at early (1, 3, 7 days) and late (1, 3, 6, 12, 18, 24 months) follow-up. All patients received immunosuppressive treatment with cyclosporine (1-3 mg/kg/day). Abdominal CT scans were performed postoperatively at the 1, 6, 12, 18, 24 months follow-up. Results: preoperatively antibodies could not be detected. Postoperatively,as from Ist month post-transplant, a progressive increase in % PRA was observed in ail patients, tip to the 12th month of follow-up. Subsequently, at18 nod 36 months, a progressive decrease in % PRA teas detected. Data showed that the recipient antibodies were directed against donor-specific antigens. During the immediate postoperative period (1, 3, 7 days) CD3- and CD4-positive T lymphocytes slightly increased, whereas CD8 simultaneously decreased. Later, CD3 and CD4 progressively decreased and CD8 increased. Clinically all patients were cured of infection at late follow-up. CT scans showedthickening of the aortic wall (range: 2.5-4.5 mm), with no signs of aneurysmal degeneration. Conclusions: fresh arterial homographs ape immunogenic. Implanted homografts induce a strong anti-HLA antibody response, similar to chronic rejection, in spite of immunosuppressive treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/08/20 alle ore 05:42:50