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Titolo:
Estroprogestin vs. gonadotrophin agonists plus estroprogestin in the treatment of endometriosis-related pelvic pain: a randomized trial
Autore:
Parazzini, F; Di Cintio, E; Chatenoud, L; Moroni, S; Ardovino, I; Struzziero, E; Falsetti, L; Bianchi, A; Bracco, G; Pellegrini, A; Bertulessi, C; Romanini, C; Zupi, E; Massobrio, M; Guidetti, D; Troiano, L; Beretta, P; Franchi, M;
Indirizzi:
Univ Milan, Prima Clin Ostetr Ginecol, Milan, Italy Univ Milan Milan Italy v Milan, Prima Clin Ostetr Ginecol, Milan, Italy Osped Civile, Benevento, Italy Osped Civile Benevento ItalyOsped Civile, Benevento, Italy Clin Ostetr Ginecol, Brescia, Italy Clin Ostetr Ginecol Brescia ItalyClin Ostetr Ginecol, Brescia, Italy Clin Ostetr Ginecol, Ferrara, Italy Clin Ostetr Ginecol Ferrara ItalyClin Ostetr Ginecol, Ferrara, Italy Clin Ostetr Ginecol, Dept 2, Florence, Italy Clin Ostetr Ginecol Florence Italy etr Ginecol, Dept 2, Florence, Italy Clin Ostetr Ginecol, Dept 1, Florence, Italy Clin Ostetr Ginecol Florence Italy etr Ginecol, Dept 1, Florence, Italy Osped M Melloni, Milan, Italy Osped M Melloni Milan ItalyOsped M Melloni, Milan, Italy Univ Roma Tor Vergata, Clin Ostetr Ginecol, Rome, Italy Univ Roma Tor Vergata Rome Italy gata, Clin Ostetr Ginecol, Rome, Italy Osped Mauriziano, Clin Ostetr Ginecol, Turin, Italy Osped Mauriziano Turin Italy riziano, Clin Ostetr Ginecol, Turin, Italy Clin Ostetr Ginecol, Trieste, Italy Clin Ostetr Ginecol Trieste ItalyClin Ostetr Ginecol, Trieste, Italy Clin Ostetr Ginecol, Varese, Italy Clin Ostetr Ginecol Varese ItalyClin Ostetr Ginecol, Varese, Italy
Titolo Testata:
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
fascicolo: 1, volume: 88, anno: 2000,
pagine: 11 - 14
SICI:
0301-2115(200001)88:1<11:EVGAPE>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DANAZOL; WOMEN;
Keywords:
estroprogestins; gonadotrophin agonists; pelvic pain; randomized trial; endometriosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Parazzini, F Mario Negri Inst Pharmacol Res, Via Eritrea 62, I-20157 Milan, Italy Mario Negri Inst Pharmacol Res Via Eritrea 62 Milan Italy I-20157
Citazione:
F. Parazzini et al., "Estroprogestin vs. gonadotrophin agonists plus estroprogestin in the treatment of endometriosis-related pelvic pain: a randomized trial", EUR J OB GY, 88(1), 2000, pp. 11-14

Abstract

Objective: This is a randomized clinical trial comparing estroprogestin (E/P) pill given for 12 months vs. gonadotrophin releasing hormone agonist (GNRHa) given for 4 months followed by E/P pill treatment for 8 months in therelief of endometriosis-related pelvic pain. Methods: Eligible for the study were women with laparoscopically confirmed endometriosis and pelvic painlasting 3-12 months after diagnosis. Eligible women were randomly assignedto treatment with E/P pill (gestroden 0.75 mg and ethynlestradiol 0.03 mg)for 12 months (47 patients) vs. tryptorelin 3.75 mg slow release every 28 days for 4 months followed by E/P pill for 8 months (55 patients). Results:Al baseline, dysmenorrhea was reported in 46 women allocated to E/P pill only (97.9%), and in all the 55 women allocated to GNRHa+E/P pill. The corresponding value at the 12 months follow-up visit was 14 subjects (35.9%) and16 subjects (34.8%). The baseline median values of the multidimensional and analog scale were for dysmenorrhea 4 and 6 in the EP only and 3 and 6 in the GNRHa+E/P group. The corresponding value at the 12 months follow-up visit were 2 and 6 and 0 and 5, Non-menstrual pain was reported, respectively,at baseline and 12 month visit by 46 (97.9%) and 15 (38.5%) subjects in the E/P pill group and 49 (89.1%) and 17 (37.0%) of the GNRHa+E/P pill one. The baseline median values of the multidimensional and analog scale were fornon-menstrual pain 3 and 5 in the E/P only and 2 and 6 in the GNRHa+E/P group. The corresponding values at the 12 month follow-up visit were 0 and 4 and 0 and 3. These differences between the two groups were not statistically significant. Conclusions: 1 year after randomization, the two treatment schedules show similar relief of pelvic pain in women with endometriosis. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 08:57:22