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Titolo:
Heterogeneity of cognitive profiles in aging: successful aging, normal aging, and individuals at risk for cognitive decline
Autore:
Ylikoski, R; Ylikoski, A; Keskivaara, P; Tilvis, R; Sulkava, R; Erkinjuntti, T;
Indirizzi:
Univ Helsinki, Cent Hosp, Memory Res Unit, Dept Clin Neurosci, FIN-00029 HYKS, Finland Univ Helsinki HYKS Finland FIN-00029 n Neurosci, FIN-00029 HYKS, Finland Univ Helsinki, Cent Hosp, Neuropsychol Unit, Dept Clin Neurosci, FIN-00029HYKS, Finland Univ Helsinki HYKS Finland FIN-00029 in Neurosci, FIN-00029HYKS, Finland Univ Helsinki, Dept Psychol, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 ol, FIN-00014 Helsinki, Finland Univ Helsinki, Dept Geriatr, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 tr, FIN-00014 Helsinki, Finland Univ Kuopio, Dept Publ Hlth & Gen Practice, FIN-70211 Kuopio, Finland UnivKuopio Kuopio Finland FIN-70211 Practice, FIN-70211 Kuopio, Finland
Titolo Testata:
EUROPEAN JOURNAL OF NEUROLOGY
fascicolo: 6, volume: 6, anno: 1999,
pagine: 645 - 652
SICI:
1351-5101(199911)6:6<645:HOCPIA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEALTHY ELDERLY PERSONS; ALZHEIMERS-DISEASE; MEMORY IMPAIRMENT; DEMENTIA; AGE; PREDICTORS; PREVALENCE; POPULATION; COMMUNITY;
Keywords:
aging; cognition; neuropsychology; heterogeneity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Ylikoski, R Univ Helsinki, Cent Hosp, Memory Res Unit, Dept Clin Neurosci,POB 300, FIN-00029 HYKS, Finland Univ Helsinki POB 300 HYKS Finland FIN-00029 29 HYKS, Finland
Citazione:
R. Ylikoski et al., "Heterogeneity of cognitive profiles in aging: successful aging, normal aging, and individuals at risk for cognitive decline", EUR J NEUR, 6(6), 1999, pp. 645-652

Abstract

Neuropsychological clinical decision-making is complicated by the fact that variability in test performance increases with advancing age. This research explores the presence of homogeneous subgroups in 120 neurologically healthy individuals, from 55 to 85 years of age. Subjects at risk for dementing diseases were diagnosed as Aging-Associated Cognitive Decline (AACD) and Mild Cognitive Impairment (MCI). Cluster analysis was applied on 11 neuropsychological variables assessing logical memory immediate recall and retention percentage, visual memory immediate recall and retention, conceptual thinking, naming, verbal fluency, constructional functions, motor speed, flexibility and finger tapping. Five clusters were extracted, one representing cognitively successfully aged, and two consisting of individuals with normalor average level of performance. One cluster was characterized by older subjects with difficulties in visual memory, visuoconstructional functions, and speed and attention, most of the younger subjects in the same cluster had a diagnosis of AACD or MCI. The fifth cluster represented individuals at risk for dementing diseases; most of them were diagnosed having AACD and more than half had a diagnosis of MCI. Age, activity and intellectual levels,and to a lesser degree education, were significantly related to the cluster solution. The present findings caution against treating samples of elderly individuals as homogeneous. fur J Neurol 6:645652 (C) 1999 Lippincott Williams & Wilkins.

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Documento generato il 25/11/20 alle ore 05:35:42