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Titolo:
A ubiquitin-like protein which is synergistically inducible by interferon-gamma and tumor necrosis factor-alpha
Autore:
Raasi, S; Schmidtke, G; de Giuli, R; Groettrup, M;
Indirizzi:
Cantonal Hosp St Gall, Dept Res, St Gallen, Switzerland Cantonal Hosp St Gall St Gallen Switzerland Res, St Gallen, Switzerland
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 12, volume: 29, anno: 1999,
pagine: 4030 - 4036
SICI:
0014-2980(199912)29:12<4030:AUPWIS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDENTIFICATION; HOMOLOGY; REGION; CELLS; GENES; CHAIN;
Keywords:
ubiquitin; antigen presentation; IFN-gamma; TNF-alpha;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Groettrup, M Kantonsspital, Lab Forsch Abt, Haus 09, CH-9007 St Gallen, Switzerland Kantonsspital Haus 09 St Gallen Switzerland CH-9007 tzerland
Citazione:
S. Raasi et al., "A ubiquitin-like protein which is synergistically inducible by interferon-gamma and tumor necrosis factor-alpha", EUR J IMMUN, 29(12), 1999, pp. 4030-4036

Abstract

A means of regulating the fate of intracellular proteins is their covalentconjugation to ubiquitin-like proteins. A recently discovered ubiquitin-like protein is called "diubiquitin" because it consists of two ubiquitin-like domains in head-to-tail arrangement. Human diubiquitin is encoded at the telomeric end of the MHC class I locus and was previously found to be expressed in dendritic cells and mature B cells. We have extended the expressionanalysis of diubiquitin by reverse transcriptase-PCR and Northern blottingin primary endothelial cells and human cancer cell lines derived from ninedifferent tissues. Diubiquitin expression was found to be generally and synergistically inducible with the cytokines IFN-gamma and TNF-alpha but not with IFN-alpha. Diubiquitin mRNA expression was induced within 2 h after cytokine stimulation and was independent of protein neosynthesis but dependent on proteasome activity. The mouse homologue of diubiquitin which is also encoded in the MHC class I locus was likewise induced with IFN-gamma and TNF-alpha. A general and synergistic induction with IFN-gamma and TNF-alpha suggests that diubiquitin may exert its functions in antigen presentation orother cellular processes controlled by these two cytokines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 10:22:55