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Titolo:
Arterial/venous plasma nicotine concentrations following nicotine nasal spray
Autore:
Guthrie, SK; Zubieta, JK; Ohl, L; Ni, L; Koeppe, RA; Minoshima, S; Domino, EF;
Indirizzi:
Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 t Pharmacol, Ann Arbor, MI 48109 USA Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 pt Psychiat, Ann Arbor, MI 48109 USA Univ Michigan, Dept Nucl Med, Sect Internal Med, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 nternal Med, Ann Arbor, MI 48109 USA Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 th Res Inst, Ann Arbor, MI 48109 USA Univ Michigan, Coll Pharm, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Coll Pharm, Ann Arbor, MI 48109 USA
Titolo Testata:
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
fascicolo: 9, volume: 55, anno: 1999,
pagine: 639 - 643
SICI:
0031-6970(199911)55:9<639:APNCFN>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUG CONCENTRATION; CIGARETTE-SMOKING; COTININE; BLOOD;
Keywords:
nicotine; cotinine; nasal administration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Domino, EF Univ Michigan, Dept Pharmacol, 1150W Med Ctr Dr, Ann Arbor, MI 48109 USA Univ Michigan 1150W Med Ctr Dr Ann Arbor MI USA 48109 48109 USA
Citazione:
S.K. Guthrie et al., "Arterial/venous plasma nicotine concentrations following nicotine nasal spray", EUR J CL PH, 55(9), 1999, pp. 639-643

Abstract

Background and objectives: Arterial (A) and venous (V) plasma nicotine andcotinine concentrations were measured after nasal nicotine spray in tobacco smokers of both genders. The hypothesis for this research was that a greater A/V difference in plasma nicotine would be present in males than females because males have greater skeletal muscle mass to bind nicotine. Subjects and methods: Nine male and nine female healthy adult smokers werestudied. They all abstained from use of tobacco overnight for 10 h or moreprior to the study. Nicotine nasal spray was given in doses of 1-2.5 mg total, with half in each nostril while the subject was supine. Both A and V blood samples were obtained prior to and 3, 6, 10, 15, 20, and 30 min post-nasal nicotine spray. Results and conclusions: Nasal nicotine administration produced greater A than V plasma levels. There were no gender differences in A/V nicotine concentrations, disproving the above hypothesis, suggesting that other physiochemical factors besides skeletal muscle mass must be involved. Heart rate increases correlated well with arterial plasma nicotine levels (r = 0.77). Males had less variance than females in the expected increase in arterial plasma nicotine concentrations with increased number of nasal sprays. Althoughthere was considerable overlap, mean A cotinine concentrations were consistently slightly larger than V concentrations.

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Documento generato il 02/07/20 alle ore 18:54:47