Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Neurophysiology of Parkinson's disease: from basic research to clinical correlates
Autore:
Centonze, D; Calabresi, P; Giacomini, P; Bernardi, G;
Indirizzi:
Univ Roma Tor Vergata, Dipartimento Neurosci, Neurol Clin, I-00133 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00133 eurol Clin, I-00133 Rome, Italy Osped S Lucia, IRCCS, Rome, Italy Osped S Lucia Rome ItalyOsped S Lucia, IRCCS, Rome, Italy Univ La Sapienza, Neurol Clin 2, I-00185 Rome, Italy Univ La Sapienza Rome Italy I-00185 , Neurol Clin 2, I-00185 Rome, Italy
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 12, volume: 110, anno: 1999,
pagine: 2006 - 2013
SICI:
1388-2457(199912)110:12<2006:NOPDFB>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; GLUTAMIC-ACID DECARBOXYLASE; STRIATAL SPINY NEURONS; RAT NEOSTRIATUM; BASAL GANGLIA; SYNAPTIC PLASTICITY; MESSENGER-RNA; DOPAMINERGIC DEAFFERENTATION; 6-HYDROXYDOPAMINE LESIONS; CHOLINERGIC INTERNEURONS;
Keywords:
Parkinson's disease; dopamine; nigrostriatal neurones;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Calabresi, P Univ Roma Tor Vergata, Dipartimento Neurosci, Neurol Clin, Via Tor Vergata135, I-00133 Rome, Italy Univ Roma Tor Vergata Via Tor Vergata135 Rome Italy I-00133
Citazione:
D. Centonze et al., "Neurophysiology of Parkinson's disease: from basic research to clinical correlates", CLIN NEU, 110(12), 1999, pp. 2006-2013

Abstract

The aim of the present review is to discuss recent acquisitions on the neurophysiological effects of the DA denervation of the striatum, obtained in vitro from single neurone electrophysiological recordings. Nigrostriatal DAsystem degeneration does not significantly alter the intrinsic properties of striatal cells, but triggers adaptive responses in the striatum, involving glutamatergic neurotransmission. By pairing intracellular recordings from 6-OHDA-denervated striatal projection neurones and the synaptic stimulation of glutamatergic corticostriatal pathway, in vitro experiments contributed to elucidate the intimate alterations that follow striatal DA deafferentation. This experimental approach also allowed to better understand the possible cellular bases of both beneficial and side effects of the pharmacological compounds commonly employed in the treatment of PD. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:46:16