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Titolo:
Changes in plasma cystatin C after renal transplantation and acute rejection in adults
Autore:
Le Bricon, T; Thervet, E; Benlakehal, M; Bousquet, B; Legendre, C; Erlich, D;
Indirizzi:
Hop St Louis, Lab Biochim B, F-75475 Paris 10, France Hop St Louis ParisFrance 10 is, Lab Biochim B, F-75475 Paris 10, France Hop St Louis, Serv Nephrol & Transplantat Renale, F-75475 Paris, France Hop St Louis Paris France F-75475 splantat Renale, F-75475 Paris, France Hop St Louis, Lab Biochim A, F-75475 Paris 10, France Hop St Louis ParisFrance 10 is, Lab Biochim A, F-75475 Paris 10, France
Titolo Testata:
CLINICAL CHEMISTRY
fascicolo: 12, volume: 45, anno: 1999,
pagine: 2243 - 2249
SICI:
0009-9147(199912)45:12<2243:CIPCCA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION RATE; SERUM CREATININE; BIOLOGICAL VARIATION; SENSITIVE MARKER; IMMUNOASSAY; PREDICTION; CLEARANCE; GFR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Erlich, D Hop St Louis, Lab Biochim B, 1 Ave Claude Vellefaux, F-75475 Paris 10, France Hop St Louis 1 Ave Claude Vellefaux Paris France 10 10, France
Citazione:
T. Le Bricon et al., "Changes in plasma cystatin C after renal transplantation and acute rejection in adults", CLIN CHEM, 45(12), 1999, pp. 2243-2249

Abstract

Background: Cystatin C has recently been proposed as an alternative markerof glomerular filtration rate. The diagnostic value of plasma cystatin C for the longitudinal assessment of kidney function after renal transplantation, however, has not been addressed. Methods: Renal function was evaluated in 30 adults receiving renal transplants (46 +/- 9 years, mean +/- SD) and in 56 healthy controls (38 +/- 10 years) using cystatin C, Plasma cystatin C was determined daily starting the day of surgery and for 3 weeks after surgery by an immunonephelometric assay. Results: Plasma concentration significantly decreased during the first week (-44% vs -29% for creatinine). Plasma cystatin C correlated with plasma creatinine (r = 0.741; P <0.0001) and the reciprocal of the creatinine clearance estimated by the Cockcroft-Gault formula (r = 0.882; P <0.001). In allthree cases of acute renal impairment, the increase in plasma cystatin C values was more prominent than that of creatinine. Conclusions: Plasma cystatin C is an alternative and accurate marker of allograft function in adult transplant patients. Increased sensitivity compared with creatinine for the detection of acute reduction in glomerular filtration rate allows in some cases a more rapid diagnosis of acute rejection or treatment nephrotoxicity. (C) 1999 American Association for Clinical Chemistry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 05:17:22