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Titolo:
Gene therapy in the cardiovascular system: an update
Autore:
Sinnaeve, P; Varenne, O; Collen, D; Janssens, S;
Indirizzi:
Katholieke Univ Leuven, Flanders Interuniv Inst Biotechnol, Ctr Transgene Technol & Gene Therapy, B-3000 Louvain, Belgium Katholieke Univ Leuven Louvain Belgium B-3000 y, B-3000 Louvain, Belgium Katholieke Univ Leuven, Hosp Gasthuisberg, Cardiac Unit, Louvain, Belgium Katholieke Univ Leuven Louvain Belgium , Cardiac Unit, Louvain, Belgium Hop Bichat, Cardiac Unit, F-75877 Paris, France Hop Bichat Paris France F-75877 hat, Cardiac Unit, F-75877 Paris, France
Titolo Testata:
CARDIOVASCULAR RESEARCH
fascicolo: 3, volume: 44, anno: 1999,
pagine: 498 - 506
SICI:
0008-6363(199912)44:3<498:GTITCS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; ENDOTHELIAL GROWTH-FACTOR; COLLATERAL VESSEL DEVELOPMENT; ADENOVIRUS-MEDIATED TRANSFER; IN-VIVO; NEOINTIMAL FORMATION; CORONARY-ARTERY; FAMILIAL HYPERCHOLESTEROLEMIA; FUTURE-PROSPECTS; RECEPTOR GENE;
Keywords:
atherosclerosis; gene therapy; heart failure; hypertension; infection/inflammation; thrombosis/embolism;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
125
Recensione:
Indirizzi per estratti:
Indirizzo: Janssens, S Katholieke Univ Leuven, Flanders Interuniv Inst Biotechnol, Ctr Transgene Technol & Gene Therapy, Campus Gasthuisberg,Herestr 49, B-3000 Louvain, Belgium Katholieke Univ Leuven Campus Gasthuisberg,Herestr 49 Louvain Belgium B-3000
Citazione:
P. Sinnaeve et al., "Gene therapy in the cardiovascular system: an update", CARDIO RES, 44(3), 1999, pp. 498-506

Abstract

This update reviews the remarkable progression in several cardiovascular gene transfer domains. The first chemical gene therapy protocols to stimulate angiogenesis in ischemic myocardium are discussed and both the great expectations as well as remaining hurdles are highlighted. In experimental models of restenosis and heart failure gene therapy shows promising results. Important questions regarding vector-related limitations and suboptimal in vivo delivery systems will require expeditious attention for gene therapy to become a more widely applicable option in cardiovascular diseases. (C) 1999Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:56:53